Smoothened receptor inhibitor vismodegib for the treatment of basal cell carcinoma: a retrospective analysis of efficacy and side effects
| Autor: | Kende Lőrincz, Norbert Kiss, Norbert Wikonkál, Pálma Anker, Luca Fésűs, Nóra Gyöngyösi, Dalma Fanni Márton, András Bánvölgyi |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Skin Neoplasms Pyridines Nausea Vismodegib Antineoplastic Agents Nevoid basal-cell carcinoma syndrome Dermatology Gastroenterology 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Anilides Basal cell carcinoma Adverse effect Aged Retrospective Studies 030203 arthritis & rheumatology business.industry Alopecia Middle Aged medicine.disease Smoothened Receptor Dysgeusia Discontinuation stomatognathic diseases Carcinoma Basal Cell Female Neoplasm Recurrence Local medicine.symptom business Muscle cramp medicine.drug |
| Zdroj: | Journal of Dermatological Treatment. 31:387-398 |
| ISSN: | 1471-1753 0954-6634 |
| DOI: | 10.1080/09546634.2019.1601155 |
| Popis: | Background: Smoothened receptor inhibitor vismodegib is indicated to treat locally advanced basal cell carcinoma (laBCC) and lesions in nevoid basal cell carcinoma syndrome (NBCCS).Methods: We treated 11 patients - including four NBCCS and seven laBCC patients - with vismodegib at our department.Results: Complete remission was achieved in three cases, without relapse after discontinuation. Two of the aforementioned patients had NBCCS, in their cases further treatment might be needed. Two patients showed improvement, but later passed away due to unrelated conditions. Two patients with laBCC initially showed remission, then the treatment was suspended due to side effects. After re-administration of the drug, loss of efficacy was observed. We did not observe therapy resistance in our NBCCS group. The rest of the patients showed good response to therapy, but have not reached full remission yet. The main side effects of vismodegib were muscle cramps, dysgeusia, nausea and alopecia. The frequency of adverse events did not show significant differences between the patient groups.Conclusions: Our results show that vismodegib therapy is effective in the treatment of BCC; however, side effects are often severe. Since the suspension of treatment can lead to therapy resistance, the management of side effects is of great importance. |
| Databáze: | OpenAIRE |
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