Deformation-based shape analysis of the hippocampus in the semantic variant of primary progressive aphasia and Alzheimer’s disease
| Autor: | Maria Luisa Gorno-Tempini, Howard J. Rosen, M. Mallar Chakravarty, Christophe Bedetti, Marianne Chapleau, Simona Maria Brambati, Signy Sheldon, Bruce L. Miller, Gabriel A. Devenyi |
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| Přispěvatelé: | Université de Montréal. Faculté des arts et des sciences. Département de psychologie |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Aging Disease Hippocampal formation Neurodegenerative Hippocampus lcsh:RC346-429 Primary progressive aphasia 0302 clinical medicine MAGeT brain Brain segmentation Medicine 2.1 Biological and endogenous factors Aetiology Semantic variant of primary progressive aphasia 05 social sciences Brain Regular Article Alzheimer's disease Middle Aged Control subjects Magnetic Resonance Imaging Hippocampal atrophy Semantics Automated segmentation Neurology Neurological Hippocampal volume Biomedical Imaging lcsh:R858-859.7 Female Alzheimer’s disease Shape analysis (digital geometry) Adult Cognitive Neuroscience Primary Progressive lcsh:Computer applications to medicine. Medical informatics 050105 experimental psychology 03 medical and health sciences Clinical Research Alzheimer Disease Aphasia Acquired Cognitive Impairment Humans 0501 psychology and cognitive sciences Radiology Nuclear Medicine and imaging lcsh:Neurology. Diseases of the nervous system Deformation-based shape analysis Aged business.industry Neurosciences Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) medicine.disease Brain Disorders Aphasia Primary Progressive Dementia Neurology (clinical) Atrophy business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | NeuroImage : Clinical NeuroImage: Clinical, Vol 27, Iss, Pp 102305-(2020) |
| ISSN: | 2213-1582 |
| Popis: | Highlights • Both svPPA and AD manifest hippocampal atrophy. • svPPA and AD have similar pattern of hippocampal shape deformation as detected by deformation-based shape analysis. • Both diseases are characterized by a lateral displacement of the central part (body) of the hippocampus. • Morphological hippocampal changes are part of the early anatomical profile of patients with svPPA. Background Increasing evidence shows that the semantic variant of primary progressive aphasia (svPPA) is characterized by hippocampal atrophy. However, less is known about disease-related morphological hippocampal changes. The goal of the present study is to conduct a detailed characterization of the impact of svPPA on global hippocampus volume and morphology compared with control subjects and patients with Alzheimer’s disease (AD). Methods We measured hippocampal volume and deformation-based shape differences in 22 patients with svPPA compared with 99 patients with AD and 92 controls. Multiple Automatically Generated Templates Brain Segmentation Algorithm (MAGeT-Brain) was used on MRI images obtained at the diagnostic visit. Results Comparable left and right hippocampal atrophy were observed in svPPA and AD. Deformation-based shape analysis showed a common pattern of morphological deformation in svPPA and AD compared with controls. More specifically, both svPPA and AD showed inward deformations in the dorsal surface of the hippocampus, from head to tail on the left side, and more limited to the anterior portion of the body in the right hemisphere. These results also pointed out that both diseases are characterized by a lateral displacement of the central part (body) of the hippocampus. Discussion Our study provides critical new evidence of hippocampal morphological changes in svPPA, similar to those found in AD. These findings highlight the importance of considering morphological hippocampal changes as part of the anatomical profile of patients with svPPA. |
| Databáze: | OpenAIRE |
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