Evidence for an Interaction between Apolipoprotein E Genotype, Gender, and Alzheimer Disease
| Autor: | Teresa E. Seeman, Gerard D. Schellenberg, J Poirier, Philip Bretsky, Victor W. Henderson, J G Buckwalter, Carol A. Miller, Caleb E. Finch |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Genetic Markers
Male Apolipoprotein E medicine.medical_specialty Genotype Apolipoprotein E4 Logistic regression Apolipoproteins E Sex Factors Alzheimer Disease Risk Factors Internal medicine Statistical significance medicine Humans Longitudinal Studies Risk factor Alleles Aged Proportional Hazards Models Retrospective Studies Aged 80 and over Proportional hazards model Odds ratio Middle Aged Confidence interval Psychiatry and Mental health Clinical Psychology Logistic Models Endocrinology Female lipids (amino acids peptides and proteins) Geriatrics and Gerontology Age of onset Psychology Gerontology |
| Zdroj: | Alzheimer Disease & Associated Disorders. 13:216-221 |
| ISSN: | 0893-0341 |
| DOI: | 10.1097/00002093-199910000-00007 |
| Popis: | Carriers of the apolipoprotein E (APOE) epsilon4 allele show significantly higher risk of Alzheimer disease (AD). The aim of this present study was to test the hypothesis that a significant interaction exists between APOE genotype and gender on AD. Interactions of epsilon4 by gender, although indicated in the literature, require further verification. A total of 195 past or current control or AD participants in an ongoing longitudinal study of aging and dementia were genotyped. All subjects were at least 60 years old; demented subjects met clinical or pathologic criteria for late-onset AD. Logistic regression analysis and proportional hazard models were used to evaluate joint effects of APOE and gender. A significant statistical interaction between APOE and gender was shown (p = 0.04) in logistic regression analysis. Women carrying one or more APOE-epsilon4 allele were more likely to develop AD [odds ratio (OR) = 7.8, 95% confidence interval (CI) = 3.2-19. 1]. For men, the presence of the APOE-epsilon4 allele was not associated with a statistically significant increased risk (OR = 1.6, 95% CI = 0.5-5.3). The interaction term in the proportional hazards model neared (p = 0.07) statistical significance, and a similar but reduced gender effect was shown. The analysis suggests that the presence of one or more APOE-epsilon4 allele confers a substantially greater risk of AD to women than to men. These findings in part may account for reports of increased risk of AD faced by women. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|