Exploring myocardial fibrosis in severe aortic stenosis: echo, CMR and histology data from FIB-AS study
| Autor: | Giedrė Balčiūnaitė, Justinas Besusparis, Darius Palionis, Edvardas Žurauskas, Viktor Skorniakov, Vilius Janušauskas, Aleksejus Zorinas, Tomas Zaremba, Nomeda Valevičienė, Pranas Šerpytis, Audrius Aidietis, Kęstutis Ručinskas, Peter Sogaard, Sigita Glaveckaitė |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Balčiūnaitė, G, Besusparis, J, Palionis, D, Žurauskas, E, Skorniakov, V, Janušauskas, V, Zorinas, A, Zaremba, T, Valevičienė, N, Šerpytis, P, Aidietis, A, Ručinskas, K, Sogaard, P & Glaveckaitė, S 2022, ' Exploring myocardial fibrosis in severe aortic stenosis : echo, CMR and histology data from FIB-AS study ', International Journal of Cardiovascular Imaging, vol. 38, no. 7, pp. 1555-1568 . https://doi.org/10.1007/s10554-022-02543-w |
| ISSN: | 1573-0743 |
| Popis: | PurposeMyocardial fibrosis in aortic stenosis (AS) is associated with worse survival following aortic valve replacement (AVR). We assessed myocardial fibrosis in severe AS patients, integrating echocardiographic, cardiovascular magnetic resonance (CMR) and histological data. MethodsA total of 83 severe AS patients (age 66.4 ± 8.3, 42% male) who were scheduled for surgical AVR underwent CMR with late gadolinium enhancement (LGE) and T1 mapping and global longitudinal strain (GLS) analysis. Collagen volume fraction (CVF) was measured in myocardial biopsies (71) that were sampled at the time of AVR. ResultsCVF correlated with imaging and serum biomarkers of LV systolic dysfunction and left side chamber enlargement and was higher in the sub-endocardium compared with midmyocardium (p |
| Databáze: | OpenAIRE |
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