CXCR3 deletion aggravates corneal neovascularization in a corneal alkali-burn model
Autor: | Shengguo Li, Shuizhen Shi, Ban Luo, Fan Xia, Yonju Ha, Jonathan Luisi, Praveena K. Gupta, Kevin H. Merkley, Massoud Motamedi, Hua Liu, Wenbo Zhang |
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Rok vydání: | 2022 |
Předmět: |
Inflammation
History Polymers and Plastics Alkalies Industrial and Manufacturing Engineering Sensory Systems Cornea Cellular and Molecular Neuroscience Ophthalmology Mice Eye Burns Disease Models Animal Burns Chemical Animals Cytokines Corneal Neovascularization Business and International Management Corneal Injuries |
Zdroj: | Experimental eye research. 225 |
ISSN: | 1096-0007 |
Popis: | Corneal neovascularization can cause devastating consequences including vision impairment and even blindness. Corneal inflammation is a crucial factor for the induction of corneal neovascularization. Current anti-inflammatory approaches are of limited value with poor therapeutic effects. Therefore, there is an urgent need to develop new therapies that specifically modulate inflammatory pathways and inhibit neovascularization in the cornea. The interaction of chemokines and their receptors plays a key role in regulating leukocyte migration during inflammatory response. CXCR3 is essential for mediating the recruitment of activated T cells and microglia/macrophages, but the role of CXCR3 in the initiation and promotion of corneal neovascularization remains unclear. Here, we showed that the expression of CXCL10 and CXCR3 was significantly increased in the cornea after alkali burn. Compared with WT mice, CXCR3 |
Databáze: | OpenAIRE |
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