Sortase transpeptidases: insights into mechanism, substrate specificity, and inhibition
| Autor: | Dewey G. McCafferty, Kathleen W. Clancy, Jeffrey A. Melvin |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
medicine.drug_class
Gram-positive bacteria Antibiotics Biophysics Biology Gram-Positive Bacteria Biochemistry Article Microbiology Substrate Specificity Biomaterials Antibiotic resistance Bacterial Proteins Sortase Drug Resistance Bacterial medicine Enzyme Inhibitors Organic Chemistry General Medicine Antimicrobial biology.organism_classification Aminoacyltransferases Enzyme structure Anti-Bacterial Agents Cysteine Endopeptidases Sortase A Bacteria |
| Zdroj: | Biopolymers. 94(4) |
| ISSN: | 0006-3525 |
| Popis: | Gram-positive bacteria pose a serious healthcare threat. The growing antibiotic resistance epidemic creates a dire need for new antibiotic targets. The sortase family of enzymes is a promising target for antimicrobial therapy. This review covers the current knowledge of the mechanism, substrate specificity, and inhibitory studies of the Gram-positive bacterial [corrected] enzyme sortase. |
| Databáze: | OpenAIRE |
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