Repeatability, reproducibility, and agreement of three tonometers for measuring intraocular pressure in rabbits
| Autor: | Tos T. J. M. Berendschot, Jarno E J Wolters, Marlies Gijs, Christian J. F. Bertens, Henny J. M. Beckers, Theo G. M. F. Gorgels, Ralph van Mechelen, Rudy M.M.A. Nuijts |
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| Přispěvatelé: | Oogheelkunde, RS: MHeNs - R3 - Neuroscience, MUMC+: MA Oogheelkunde (9), MUMC+: AB Onderzoekers (9), MUMC+: AB Refractie Chirurgie Oogheelkunde (9), MUMC+: MA AIOS Oogheelkunde (9) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Animal Experimentation
medicine.medical_specialty Intraocular pressure Manometry Sedation Coefficient of variation Science Article Tonometry Ocular TEAR PRODUCTION Medical research Ophthalmology TONOVET(R) REBOUND TONOMETER medicine Animals Anesthesia APPLANATION TONOMETER New zealand white CENTRAL CORNEAL THICKNESS Sensors and probes Intraocular Pressure Reproducibility Multidisciplinary OPHTHALMIC DIAGNOSTIC-TESTS business.industry Applanation tonometer CIRCADIAN-RHYTHM Reproducibility of Results Repeatability NONINVASIVE MEASUREMENT REFERENCE VALUES OCULAR DISEASE MACAQUES MACACA-MULATTA Reference values Medicine Rabbits Visual system medicine.symptom business |
| Zdroj: | Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021) Scientific Reports Scientific Reports, 11(1):19217. Nature Publishing Group |
| ISSN: | 2045-2322 |
| Popis: | The aim of this study was to evaluate repeatability, reproducibility, and agreement of three commonly used tonometers in animal research (TonoLab, TonoVet, and TonoPEN AVIA) in a cohort of 24 rabbits. Additionally, the impact of sedation on IOP was investigated in 21 New Zealand White rabbits with the TonoVet tonometer. Repeatability was determined using the coefficient of variation (CoV) for two observers. For the TonoLab (6.55%) and TonoVet (6.38%) the CoV was lower than for the TonoPEN AVIA (10.88%). The reproducibility was highest for the TonoVet (0.2 ± 3.3 mmHg), followed by the TonoLab (0 ± 12.89 mmHg) and lowest for the TonoPEN AVIA (− 1.48 ± 10.3 mmHg). The TonoLab and TonoVet showed the highest agreement (r = 0.85, R2 = 0.73). After sedation, a significant IOP reduction (often > 25%) was observed. Our results show that among the three tonometers tested, the TonoVet tonometer is best for use in rabbits while the TonoLab should be avoided. The impact of sedation on IOP was substantial and should be taken into account during experimentation. |
| Databáze: | OpenAIRE |
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