Brain-derived neurotrophic factor is expressed in a gradient in the superior colliculus during development of the retinocollicular projection

Autor:	Sonal Jhaveri, Lauren R. Marotte, Maria Vidovic, E Wheeler
Rok vydání:	2004
Předmět:	Aging Superior Colliculi Tropomyosin receptor kinase B In situ hybridization Visual system Biology Retina Neurotrophic factors medicine Animals Receptor trkB Visual Pathways RNA Messenger In Situ Hybridization Macropodidae Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor General Neuroscience Superior colliculus Gene Expression Regulation Developmental Immunohistochemistry medicine.anatomical_structure Animals Newborn nervous system Retinal ganglion cell Neuroscience
Zdroj:	European Journal of Neuroscience. 20:843-847
ISSN:	1460-9568 0953-816X
DOI:	10.1111/j.1460-9568.2004.03521.x
Popis:	Theoretical models of topographic map formation have postulated a gradient of attractant in addition to a gradient of repulsion in the target. In species where many axons grow past their correct positions initially, it has also been argued that a parallel gradient of attractant or branching signal is required to ensure collateral formation at the correct position (O'Leary et al., 1999). Brain-derived neurotrophic factor (BDNF) is a known attractant and promotes branching of retinal axons. We have examined its distribution in the superior colliculus and that of its receptor, trkB, in the retina, using immunohistochemistry and in situ hybridization, respectively, during the development of the topographic retinocollicular projection in the wallaby, a marsupial mammal. The number of glial endfeet expressing BDNF at the surface of the colliculus was found to be in a high caudal-to-low rostral gradient during the time when the retinocollicular projection was developing. When the projection was mature the rostrocaudal gradient had disappeared and the number of detectable endfeet expressing BDNF was very low. Messenger RNA for TrkB was expressed in the retinal ganglion cell layer throughout the time when the retinocollicular projection was developing, with no difference in expression across the nasotemporal axis of the retina. The low rostral to high caudal distribution of BDNF in glial endfeet supports the idea that it is providing a parallel gradient of attractant or branching signal in the colliculus.
Databáze:	OpenAIRE
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