Emerging multidrug-resistant hybrid pathotype shiga toxin-producing Escherichia coli o80 and related strains of clonal complex 165, Europe
| Autor: | Estelle Loukiadis, Stéphane Bonacorsi, Céline Courroux, Patrick Fach, Jorge Blanco, Sabine Delannoy, Philippe Bidet, Sandrine Liguori, Patricia Mariani-Kurkdjian, Aurélie Cointe, André Birgy |
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| Přispěvatelé: | Hôpital Robert-Debré, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Paris Diderot - Paris 7 (UPD7), Université Paris-Sorbonne (UP4), Universidade de Santiago de Compostela [Spain] (USC ), Laboratoire d'Ecologie Microbienne - UMR 5557 (LEM), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Ecole Nationale Vétérinaire de Lyon (ENVL), Fonds d'Etudes et de Recherche du Corps Medical, AP-HP, Conselleria de Cultura, Educacion e Ordenacion Universitaria (Xunta de Galicia) [ED431C-2017-57], European Regional Development Fund, Assistance Publique - Hôpitaux de Paris (AP-HP), Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Vétérinaire de Lyon (ENVL)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Recherche Agronomique (INRA)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS), Universidade de Santiago de Compostela. Departamento de Microbioloxía e Parasitoloxía |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Epidemiology Shiga toxin-producing E. coli lcsh:Medicine medicine.disease_cause Communicable Diseases Emerging Plasmid Immunologie CC165 bacteria Escherichia coli Infections EHEC Escherichia coli Europe STEC antimicrobial resistance clonal complex emergence enteric infections enterohemorrhagic E. coli extra-intestinal virulence food safety foodborne diseases hybrid pathotype multidrug resistance whole-genome sequencing 2. Zero hunger [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases biology Shiga-Toxigenic Escherichia coli Virulence Emerging diseases Shiga toxin Genomics Multidrug-Resistant 3. Good health Infectious Diseases [SDV.IMM]Life Sciences [q-bio]/Immunology Microbiology (medical) Clonal Complex 165 Virulence Factors 030106 microbiology Immunology Maladies émergentes Microbiology lcsh:Infectious and parasitic diseases 03 medical and health sciences Antibiotic resistance medicine Humans lcsh:RC109-216 Hybrid Pathotype Shiga Toxin Gene Research lcsh:R biology.organism_classification Emerging Multidrug-Resistant Hybrid Pathotype Shiga Toxin–Producing Escherichia coli O80 and Related Strains of Clonal Complex 165 Europe Coli O80 Multiple drug resistance 030104 developmental biology biology.protein Bacteria Genome Bacterial Multilocus Sequence Typing |
| Zdroj: | Emerging Infectious Diseases Emerging Infectious Diseases, Centers for Disease Control and Prevention, 2018, 24 (12), pp.2262-2269. ⟨10.3201/eid2412.180272⟩ Emerging Infectious Diseases, Vol 24, Iss 12, Pp 2262-2269 (2018) Emerging Infectious Diseases 12 (24), 2262-2269. (2018) Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela instname |
| ISSN: | 1080-6040 1080-6059 |
| Popis: | Enterohemorrhagic Escherichia coli serogroup O80, involved in hemolytic uremic syndrome associated with extraintestinal infections, has emerged in France. We obtained circularized sequences of the O80 strain RDEx444, responsible for hemolytic uremic syndrome with bacteremia, and noncircularized sequences of 35 O80 E. coli isolated from humans and animals in Europe with or without Shiga toxin genes. RDEx444 harbored a mosaic plasmid, pR444_A, combining extraintestinal virulence determinants and a multidrug resistance– encoding island. All strains belonged to clonal complex 165, which is distantly related to other major enterohemorrhagic E. coli lineages. All stx-positive strains contained eae-ξ, ehxA, and genes characteristic of pR444_A. Among stx-negative strains, 1 produced extended-spectrum β-lactamase, 1 harbored the colistin-resistance gene mcr1, and 2 possessed genes characteristic of enteropathogenic and pyelonephritis E. coli. Because O80–clonal complex 165 strains can integrate intestinal and extraintestinal virulence factors in combination with diverse drug-resistance genes, they constitute dangerous and versatile multidrug-resistant pathogens We thank Roger Stephan and Lothar Beutin for providing the strains from Switzerland and Germany, respectively. This work was financed by Fonds d’Etudes et de Recherche du Corps Médical, AP-HP. Work in the Laboratorio de Referencia de Escherichia coli was financed by grant no. ED431C-2017-57 from Consellería de Cultura, Educación e Ordenación Universitaria (Xunta de Galicia) and the European Regional Development Fund SI |
| Databáze: | OpenAIRE |
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