In vitro effects of lonidamine and 6-aminonicotinamide against Echinococcus granulosussensu stricto and Echinococcus multilocularis
| Autor: | Tao Jing, Miaomiao Yuan, Li Huanping, Song Xiaoxia, Qi Xin, Jun Lu |
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| Rok vydání: | 2019 |
| Předmět: |
Indazoles
[SDV]Life Sciences [q-bio] 030231 tropical medicine Short Report Pharmacology Echinococcus multilocularis Zoonotic disease 03 medical and health sciences Drug treatment chemistry.chemical_compound 0302 clinical medicine Echinococcosis parasitic diseases medicine Animals 030304 developmental biology 0303 health sciences lcsh:Veterinary medicine General Veterinary biology Echinococcus granulosus Lonidamine Anticestodal Agents biology.organism_classification medicine.disease In vitro 3. Good health Echinococcus 6-Aminonicotinamide chemistry Larva lcsh:SF600-1100 Genus Echinococcus |
| Zdroj: | Veterinary Research Veterinary Research, Vol 51, Iss 1, Pp 1-7 (2020) Veterinary Research, BioMed Central, 2020, 51 (1), pp.29. ⟨10.1186/s13567-020-00744-6⟩ |
| ISSN: | 1297-9716 0928-4249 |
| DOI: | 10.1186/s13567-020-00744-6⟩ |
| Popis: | Echinococcosis is a zoonotic disease caused by cestode species of the genus Echinococcus, which demonstrates considerable medical and veterinary concerns. The development of novel drugs for echinococcosis treatment is urgently needed. In this study, we demonstrated that lonidamine (LND) and 6-aminonicotinamide (6-AN) exhibited considerable in vitro effects against both larval- and adult-stage of E. granulosussensu stricto (s. s.) and E. multilocularis. The combination of LND and 6-AN exhibited a significantly higher activity than the single drug treatment. These results highlight the therapeutic potential of LND, 6-AN and the combination of LND and 6-AN for the treatment of echinococcosis. |
| Databáze: | OpenAIRE |
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