Circular RNAs in osteoporosis: expression, functions and roles
| Autor: | Yize Liu, Yuanzhuang Zhang, Yinzhou Luo, Yong Wang, Yuan Cao, Yeqiu Xu, Guanzhen Qiu, Shanshan Li |
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| Rok vydání: | 2021 |
| Předmět: |
musculoskeletal diseases
Cancer Research QH573-671 Immunology Osteoporosis Neoplasms. Tumors. Oncology. Including cancer and carcinogens Osteoblast Cell Biology Review Article Biology medicine.disease Bone resorption Non-coding RNAs Cell biology Bone remodeling Cellular and Molecular Neuroscience medicine.anatomical_structure Osteoclast Osteocyte medicine Long non-coding RNAs Osteosarcoma Cytology Function (biology) RC254-282 |
| Zdroj: | Cell Death Discovery Cell Death Discovery, Vol 7, Iss 1, Pp 1-8 (2021) |
| ISSN: | 2058-7716 |
| Popis: | Osteoporosis, which is caused by an imbalance in osteoblasts and osteoclasts, is a global age-related metabolic disease. Osteoblasts induce osteocyte and bone matrix formation, while osteoclasts play an important role in bone resorption. Maintaining a balance between osteoblast formation and osteoclastic absorption is crucial for bone remodeling. Circular RNAs (circRNAs), which are characterized by closed-loop structures, are a class of novel endogenous transcripts with limited protein-coding abilities. Accumulating evidence indicates that circRNAs play important roles in various bone diseases, such as osteosarcoma, osteoarthritis, osteonecrosis, and osteoporosis. Recent studies have shown that circRNAs regulate osteoblast and osteoclast differentiation and may be potential biomarkers for osteoporosis. In the current review, we summarize the expression, function, and working mechanisms of circRNAs involved in osteoblasts, osteoclast differentiation, and osteoporosis. |
| Databáze: | OpenAIRE |
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