A novel submandibular gland peptide protects against endotoxic and anaphylactic shock
| Autor: | A. D. Befus, J. S. Davison, Ronald Mathison |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Hypersensitivity
Immediate Lipopolysaccharides medicine.medical_specialty Physiology Submandibular Gland Prohormone Inflammation Biology Rats Sprague-Dawley stomatognathic system Physiology (medical) Internal medicine medicine Animals Endocrine system Amino Acid Sequence Anaphylaxis Chromatography High Pressure Liquid Strongylida Infections Analysis of Variance Gastrointestinal tract Salivary gland Tissue Extracts Salmonella typhi Shock Septic Submandibular gland Rats stomatognathic diseases medicine.anatomical_structure Endocrinology Shock (circulatory) Nippostrongylus Hypotension medicine.symptom Oligopeptides Homeostasis medicine.drug |
| Zdroj: | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 273:R1017-R1023 |
| ISSN: | 1522-1490 0363-6119 |
| DOI: | 10.1152/ajpregu.1997.273.3.r1017 |
| Popis: | Submandibular glands release peptides and proteins that, through exocrine and endocrine actions, facilitate tissue repair in the oral cavity, gastrointestinal tract, and more distal sites such as liver. It has been shown that salivary gland factors also modulate inflammatory responses, because we found that removal of the submandibular glands increases the hypotensive responses to endotoxin. From this observation we proposed that these glands contain a factor that regulates cardiovascular response to shock. With the use of classical peptide isolation procedures, a heptapeptide (TDIFEGG) called submandibular gland peptide T was identified in rat submandibular glands. A synthetic form of this peptide reduced endotoxic shock in sialadenectomized rats by 50% at doses as low as 1 microgram/kg and prevented allergen-induced hypotension by 90% in rats with intact salivary glands at a dose of 100 micrograms/kg. This novel peptide is probably generated from a prohormone, submandibular gland rat 1 protein, a product of the VCSA1 gene. These data indicate that submandibular glands participate in the regulation of systemic homeostasis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|