Neutrophil-to-lymphocyte ratio in relation to the risk of all-cause mortality and cardiovascular events in patients with chronic kidney disease: a systematic review and meta-analysis
| Autor: | Shu-Man Tao, Gui-Ling Liu, Wen-Man Zhao |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Neutrophils 030232 urology & nephrology 030204 cardiovascular system & hematology Critical Care and Intensive Care Medicine lcsh:RC870-923 Gastroenterology Risk Assessment 03 medical and health sciences Leukocyte Count cardiovascular events 0302 clinical medicine neutrophil-to-lymphocyte ratio Internal medicine Cause of Death Medicine Humans In patient Lymphocytes Neutrophil to lymphocyte ratio Renal Insufficiency Chronic business.industry fungi General Medicine medicine.disease lcsh:Diseases of the genitourinary system. Urology meta-analysis Nephrology Cardiovascular Diseases Meta-analysis Clinical Study all-cause mortality business All cause mortality Kidney disease Research Article |
| Zdroj: | Renal Failure, Vol 42, Iss 1, Pp 1059-1066 (2020) Renal Failure article-version (VoR) Version of Record |
| ISSN: | 1525-6049 |
| Popis: | Aim To systematically evaluate the relationship between the neutrophil-to-lymphocyte ratio (NLR) and the risk of all-cause mortality or cardiovascular events in patients with chronic kidney disease (CKD). Methods PubMed, Embase, and Web of Science databases were searched for cohort studies that were published since the databases were launched, until 1 April 2020. We selected papers according to specific inclusion and exclusion criteria, extracted data, and evaluated the quality of the citations. Data from eligible studies were used to calculate the combined hazard ratios (HRs) and 95% confidence intervals (CI). Results The search identified 1048 potentially eligible records, and 10 studies (n = 1442) were selected. Eight studies reported all-cause mortality, and two studies reported cardiovascular events. The combined HR of all-cause mortality was 1.45 (95% CI 1.20–1.75) and the HR of cardiovascular events was 1.52 (95% CI 1.33–1.72) when NLR was considered as a categorical variable. Similarly, the association between NLR and all-cause mortality was confirmed (HR 1.35; 95% CI 1.23–1.48) when NLR was used as a continuous variable. Conclusion NLR is a predictor of all-cause mortality and cardiovascular events in patients with chronic kidney disease. |
| Databáze: | OpenAIRE |
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