Turn-on signal fluorescence sensor based on DNA derived bio-dots/polydopamine nanoparticles for the detection of glutathione

Autor: Xiaoxiao Chen, Pu Li, Gaojun Wu, Zhe Wang, Chaobiao Huang
Rok vydání: 2022
Předmět:
Zdroj: RSC Advances. 12:1807-1812
ISSN: 2046-2069
DOI: 10.1039/d1ra08107a
Popis: A convenient, fast, sensitive and highly selective fluorescence sensor for the detection of glutathione (GSH) based on DNA derived bio-dots (DNA bio-dots)/polydopamine (PDA) nanoparticles was constructed. The fluorescent switch of DNA bio-dots was induced to turn off because of fluorescence resonance energy transfer (FRET) reactions between DNA bio-dots and PDA. The presence of GSH blocked the spontaneous oxidative polymerization of dopamine (DA) to PDA, leading the fluorescent switch of DNA bio-dots to be "turned on". The degree of fluorescence recovery of DNA bio-dots is linearly correlated with the concentration of GSH within the range of 1.00-100 μmol L
Databáze: OpenAIRE