Probiotics and prebiotics: focus on psychiatric disorders – a systematic review
| Autor: | Maria Augusta Vieira-Coelho, Renata S D Barbosa |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Gut–brain axis Medicine (miscellaneous) Context (language use) Disease Gut flora law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law medicine Humans Psychiatry Randomized Controlled Trials as Topic Nutrition and Dietetics biology business.industry Mental Disorders Probiotics biology.organism_classification medicine.disease Jadad scale Prebiotics 030104 developmental biology Systematic review Major depressive disorder business 030217 neurology & neurosurgery |
| Zdroj: | Nutrition Reviews. 78:437-450 |
| ISSN: | 1753-4887 0029-6643 |
| DOI: | 10.1093/nutrit/nuz080 |
| Popis: | Context The gut-brain axis and microbial dysbiosis may play a role in psychiatric diseases. In this view, the gut microbiota has been considered a potential therapeutic target using probiotics and prebiotics. Objective This systematic review aims to find the existing clinical evidence that may justify the use of probiotics or prebiotics in psychiatric patients. Data sources PRISMA guidelines were followed for a systematic literature review of randomized controlled trials that assessed the effect of prebiotics or probiotics in patients diagnosed with a classified psychiatric disorder. Data extraction From a total of 212 studies screened, 11 were included in the final systematic review. Quality assessment of the included trials was assessed by the Jadad scale. Results Probiotics seem to offer some benefit in major depressive disorder and Alzheimer’s disease. One study showed that probiotics reduced rehospitalization in patients with acute mania. In autism spectrum disorders, the results were controversial; however a single study found that early administration of probiotics showed a preventive role. No benefits were found for patients with schizophrenia. In most studies, no major adverse effects were reported. Conclusions Although recent findings in specific psychiatric disorders are encouraging, the use of prebiotics and probiotics in clinical practice stills lacks sufficiently robust evidence. |
| Databáze: | OpenAIRE |
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