Sex difference and possible relationship to microvascular complications of serum prorenin levels in type 2 diabetic patients, measured by a novel antibody-activating direct enzyme kinetic assay
| Autor: | Yasuo Imai, Hiroshi Tanaka, Yuichi Ishida, Shinya Minagawa, Atsuko Tsuchida, Chika Ihara, Eiji Ohmura, Fumiaki Suzuki, Masako Yazawa, Shoji Kawazu, Daiya Hosaka |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Nephropathy Immunoenzyme Techniques Endocrinology Predictive Value of Tests Internal medicine Diabetes mellitus Renin–angiotensin system Renin Internal Medicine medicine Humans Diabetic Nephropathies Aged Sex Characteristics biology business.industry Microcirculation fungi Microangiopathy Middle Aged medicine.disease Diabetes Mellitus Type 2 Hyperglycemia biology.protein Microalbuminuria Female Antibody business Biomarkers Diabetic Angiopathies Retinopathy Sex characteristics |
| Zdroj: | Journal of diabetes and its complications. 18(5) |
| ISSN: | 1056-8727 |
| Popis: | Prorenin, a precursor of renin, was measured in sera from normal subjects and type 2 diabetic patients, using a newly developed antibody-activating direct enzyme kinetic assay. Levels of prorenin were examined in relationship to diabetic microangiopathies. The levels of antibody-activating direct prorenin (AAD-PR) were approximately 1.5-fold higher than levels of prorenin measured by a conventional enzyme-activating method. AAD-PR levels were significantly higher in males than in females and in diabetic patients than in normal subjects. Moreover, AAD-PR levels were higher in diabetic patients with microalbuminuria and even higher in those with macroalbuminuria. In normoalbuminuric diabetic patients, AAD-PR levels were higher in those with retinopathy. Furthermore, a significant positive correlation was seen between the AAD-PR levels and HbA(lc) in normoalbuminuric diabetic subjects without retinopathy. Thus, the determination of circulating serum prorenin measured as AAD-PR is related to glycemia and in type 2 diabetic patients may be a risk marker of diabetic microangiopathy. More studies are necessary to determine whether AAD-PR may actually predict the development of microangiopathy. |
| Databáze: | OpenAIRE |
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