miR-142-5p Inhibits Cell Invasion and Migration by Targeting DNMT1 in Breast Cancer
| Autor: | Hui Li, Tong-Cun Zhang, Li Hanhan, Li Wang, Jia Peng Li, Yuan Xiang, Xiao-Yu Zhang, Yuan-Yuan Duan, Chang Chang Fan, Zhang Huimin, You Huang, Qian Chen, Xing-Hua Liao, Chao Jiang Gu, Yu-Yang Wang |
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| Rok vydání: | 2021 |
| Předmět: |
DNA (Cytosine-5-)-Methyltransferase 1
Cancer Research miR-142-5p Breast Neoplasms Biology Article Breast cancer Cell Movement Transcription (biology) Cell Line Tumor microRNA Transcriptional regulation medicine Humans 3' Untranslated Regions Cell Proliferation DNMT1 MKL-1 Maspin Cancer General Medicine medicine.disease Gene Expression Regulation Neoplastic MicroRNAs Oncology embryonic structures Cancer research Female Signal transduction |
| Zdroj: | Oncology Research |
| ISSN: | 0965-0407 |
| Popis: | Abnormal cell proliferation caused by abnormal transcription regulation mechanism seems to be one of the reasons for the progression of breast cancer and also the pathological basis. MicroRNA-142-5p (miR-142-5p) is a low-expressed miRNA in breast cancer. The role of MKL-1s regulation of DNMT1 in breast cancer cell proliferation and migration is still unclear. MKL-1 (myocardin related transcription factor A) can bind to the conserved cis-regulatory element CC (A/T) 6GG (called CarG box) in the promoter to regulate the transcription of miR-142-5p. The expressions of miR-142-5p and MKL-1 are positively correlated. In addition, it has been proved that DNMT1 is the target of miR-142-5p, which inhibits the expression of DNMT1 by targeting the 3-UTR of DNMT1, thereby forming a feedback loop and inhibiting the migration and proliferation of breast cancer. Our data provide important and novel insights into the MKL-1/miR-142-5p/DNMT1/maspin signaling pathway and may become a new idea for breast cancer diagnosis, treatment, and prognosis. |
| Databáze: | OpenAIRE |
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