Tests of Pituitary-Adrenal Suppressibility in the Diagnosis of Cushing??s Syndrome*???
| Autor: | Grant W. Liddle |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Pituitary gland
medicine.medical_specialty Diagnostic information Dose Pituitary Diseases Endocrinology Diabetes and Metabolism Urinary system Clinical Biochemistry Biochemistry Excretion Endocrinology Internal medicine Humans Medicine In patient Cushing Syndrome Dexamethasone Hydrocortisone S syndrome business.industry Biochemistry (medical) Adrenal Cortex Neoplasm Normal adrenal function medicine.anatomical_structure Pituitary Gland business medicine.drug |
| Zdroj: | The Endocrinologist. 15:257-278 |
| ISSN: | 1051-2144 |
| Popis: | Past attempts to test suppressibility of pituitary-adrenal function by the use of exogenous corticoids have yielded inconsistent findings in patients with Cushing's syndrome. The present study indicates that, with proper selection of suppressive agent and adjustment of dosage, valuable diagnostic information can be obtained from such tests. Δ1-9α-Fluorocortisol (ΔFF) and its 16α:-methylated analog (dexamethasone) were employed as suppressive agents. At dosage levels of 0.5 mg. every six hours for 8 doses these agents induced almost complete suppression of 17-hydroxycorticoid excretion in all 54 endocrinologically normal subjects tested. In contrast, all 35 of the patients with true Cushing's syndrome who were studied maintained relatively high urinary 17-hydroxycorticoid levels during such treatment. At these low dosages, therefore, the suppressive agents were useful in separating patients with Cushing's syndrome from those with normal adrenal function. Administration of ΔFF or dexamethasone in l... |
| Databáze: | OpenAIRE |
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