Regulation of transforming growth factor β-mediated epithelial-mesenchymal transition of lens epithelial cells by c-Src kinase under high glucose conditions
| Autor: | Qi Liu, Jian Zhou, Fu‑Lei Wang, Fang Wang, Zhi‑Hua Han |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Cancer Research Oncogene Kinase Chemistry Cell General Medicine Articles Cell cycle Cell biology 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Immunology and Microbiology (miscellaneous) Apoptosis 030220 oncology & carcinogenesis medicine Secretion Epithelial–mesenchymal transition sense organs Transforming growth factor |
| Zdroj: | Experimental and therapeutic medicine. 16(2) |
| ISSN: | 1792-0981 |
| Popis: | Recent studies have reported that high glucose (HG) conditions may contribute to the acceleration of renal cell apoptosis and renal fibrosis by inducing epithelial-mesenchymal transition (EMT) of tubular epithelial cells, in which c-Src kinase and transforming growth factor (TGF)-β are key modulators. In the present study, the roles of c-Src kinase and TGF-β in EMT of lens epithelial cells (LECs) under HG conditions were investigated. Results indicated human lens epithelial B3 (HLE-B3) cells under HG conditions exhibited significantly increased protein expression levels of phosphorylated c-Src (p-Src418) (P |
| Databáze: | OpenAIRE |
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