Severe Acute Respiratory Syndrome Coronavirus 2 P.2 Lineage Associated with Reinfection Case, Brazil, June–October 2020
| Autor: | Romero Henrique Teixeira Vasconcelos, Ana Carolina Duarte, Anna Carolina Dias Paixão, Thauane Silva, Ighor Arantes, Anderson Brandao Leite, Alex Pauvolid-Corrêa, Isabel Diniz Herbster, Luciana Appolinario, Gonzalo Bello, Thiago Franco de Oliveira Carneiro, Walquiria A. F. Almeida, João Felipe Bezerra, Ana Carolina da Fonseca Mendonça, Alice Sampaio Barreto da Rocha, Ana Beatriz Machado Lima, Mirian Livorati, Francisco Paulo Freire Neto, Felipe Gomes Naveca, Marilda M. Siqueira, Irina Nastassja Riediger, Paola Cristina Resende, Fernando Couto Motta, Maria do Carmo Debur, Dalane Loudal Florentino Teixeira |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Microbiology (medical)
Adult Lineage (genetic) Epidemiology Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Secondary infection 030231 tropical medicine Disease Infectious and parasitic diseases RC109-216 Biology medicine.disease_cause reinfection P.2 03 medical and health sciences respiratory infections 0302 clinical medicine secondary infection medicine Humans viruses 030212 general & internal medicine Clade Coronavirus SARS-CoV-2 Research Healthcare worker Spike Protein COVID-19 Bayes Theorem Severe Acute Respiratory Syndrome Coronavirus 2 Lineage Associated with Reinfection Case Brazil June–October 2020 Virology zoonoses Infectious Diseases coronavirus disease Medicine Brazil severe acute respiratory syndrome coronavirus 2 |
| Zdroj: | Emerging Infectious Diseases Emerging Infectious Diseases, Vol 27, Iss 7, Pp 1789-1794 (2021) |
| ISSN: | 1080-6059 1080-6040 |
| Popis: | A 37-year-old healthcare worker from the northeastern region of Brazil experienced 2 clinical episodes of coronavirus disease. Infection with severe acute respiratory syndrome coronavirus 2 was confirmed by reverse transcription PCR in samples collected 116 days apart. Whole-genome sequencing revealed that the 2 infections were caused by the most prevalent lineage in Brazil, B.1.1.33, and the emerging lineage P.2. The first infection occurred in June 2020; Bayesian analysis suggests reinfection at some point during September 14-October 11, 2020, a few days before the second episode of coronavirus disease. Of note, P.2 corresponds to an emergent viral lineage in Brazil that contains the mutation E484K in the spike protein. The P.2 lineage was initially detected in the state of Rio de Janeiro, and since then it has been found throughout the country. Our findings suggest not only a reinfection case but also geographic dissemination of the emerging Brazil clade P.2. |
| Databáze: | OpenAIRE |
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