Suspected metastatic adrenocortical carcinoma revealing as pulmonary Kaposi sarcoma in adrenal Cushing’s syndrome
| Autor: | Josef Pichl, Cristina L. Ronchi, Bruno Allolio, Stefan Kircher, Vanessa Wild, Margarita Bala, Stefanie Hahner |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Pathology
medicine.medical_specialty Lung Neoplasms Hydrocortisone Endocrinology Diabetes and Metabolism Hypercortisolism Adrenal carcinoma Case Report Diagnosis Differential Endocrinology Adrenocortical Carcinoma Internal Medicine medicine Humans Adrenal adenoma Adrenal Cushing's syndrome ddc:610 Cushing Syndrome Sarcoma Kaposi Multiple Pulmonary Nodules business.industry Metastatic Adrenocortical Carcinoma Kaposi sarcoma Adrenalectomy General Medicine Middle Aged Prognosis medicine.disease Adrenal Cortex Neoplasms Cushing’s syndrome Female Sarcoma business Immunosuppression Immunostaining medicine.drug |
| Zdroj: | BMC Endocrine Disorders |
| Popis: | Background Kaposi sarcoma (KS) is a malignant disease most commonly diagnosed in the setting of a human immunodeficiency virus (HIV) infection and in patients receiving immunosuppressive treatment. Pulmonary KS has never been reported in association with endogenous Cushing’s syndrome (CS). Case presentation A 60-year-old woman presented with symptoms and signs of CS. Adrenal CS was confirmed by standard biochemical evaluation. Imaging revealed a right adrenal lesion (diameter 3.5 cm) and multiple pulmonary nodules, suggesting a cortisol-secreting adrenal carcinoma with pulmonary metastases. The patient underwent right adrenalectomy with a pathohistological diagnosis of an adrenal adenoma. Subsequent thoracoscopic wedge resection of one lung lesion revealed pulmonary KS with positive immunostaining for human herpes virus 8 (HHV-8). HIV-serology was negative. Hydrocortisone replacement was initiated for secondary adrenal insufficiency after surgery. Post-operative follow up imaging showed complete remission of all KS-related pulmonary nodules solely after resolution of hypercortisolism. Conclusion KS may occur in the setting of endogenous CS and may go into remission after cure of hypercortisolism without further specific treatment. |
| Databáze: | OpenAIRE |
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