Cholesterol and the Risk of Ischemic Stroke
| Autor: | Thomas S. Bowman, J. Michael Gaziano, Howard D. Sesso, Tobias Kurth, Meir J. Stampfer, Jing Ma, Carlos S. Kase |
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| Rok vydání: | 2003 |
| Předmět: |
Male
Risk medicine.medical_specialty Comorbidity Brain Ischemia chemistry.chemical_compound Risk Factors Internal medicine Odds Ratio Humans Medicine Prospective Studies Risk factor Prospective cohort study Stroke Triglycerides Randomized Controlled Trials as Topic Advanced and Specialized Nursing business.industry Cholesterol Case-control study Odds ratio Middle Aged medicine.disease United States Confidence interval Logistic Models Endocrinology Quartile chemistry Case-Control Studies Neurology (clinical) Lipoproteins HDL Cardiology and Cardiovascular Medicine business |
| Zdroj: | Stroke. 34:2930-2934 |
| ISSN: | 1524-4628 0039-2499 |
| DOI: | 10.1161/01.str.0000102171.91292.dc |
| Popis: | Background and Purpose— Large epidemiological studies have not established cholesterol levels as a risk factor for ischemic stroke, but recent clinical trials have demonstrated a reduction in the ischemic stroke rate for patients taking HMG-CoA reductase inhibitors (“statins”). The goal of this study was to evaluate whether total cholesterol (TC), high-density lipoprotein (HDL), triglycerides, and the TC:HDL ratio are risk factors for ischemic stroke in apparently healthy men enrolled in the Physicians’ Health Study. Methods— We used a nested case-control study design and matched 296 ischemic stroke cases with an equal number of controls on age, tobacco use, and follow-up time. At baseline, TC, HDL, and triglyceride levels were measured. We calculated odds ratios (ORs) and their 95% confidence intervals (CIs) using conditional logistic regression, adjusting for major risk factors for ischemic stroke. Results— Compared with the reference lowest quartile, the highest quartile for TC had an adjusted OR of 1.56 (95% CI, 0.84 to 2.92), the highest quartile of HDL had an adjusted OR of 0.75 (95% CI, 0.43 to 1.30), and the highest quartile of triglycerides had an adjusted OR of 1.07 (95% CI, 0.63 to 1.82). Although the highest quartile of the TC:HDL ratio had an adjusted OR of 1.62 (95% CI, 0.93 to 2.82), the risk of ischemic stroke was not a linear relationship. Conclusions— After adjustment, TC, HDL, and triglycerides were not significantly associated with ischemic stroke risk, and for the TC:HDL ratio, a suggestion of increased risk of ischemic stroke was limited to those with the highest levels. |
| Databáze: | OpenAIRE |
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