Retinoic acid ortho-hydroxy aniline amide promotes neurotrophin mediated cell growth and proliferation in nerve cells
| Autor: | Yi-Hua Wang, Fang Wang, Jin-Peng Wang, Zhi-Gang Wang, Pei-Cheng Cao |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Pharmacology
Messenger RNA Stem cell Cell growth Proliferation lcsh:RM1-950 Retinoic acid Retinoic acid receptor beta Biology Molecular biology Retinoic acid amide chemistry.chemical_compound Retinoic acid receptor Aniline lcsh:Therapeutics. Pharmacology chemistry nervous system Neuronal differentiation Amide biology.protein Neurotrophin |
| Zdroj: | Bangladesh Journal of Pharmacology, Vol 10, Iss 1, Pp 40-46 (2015) Bangladesh Journal of Pharmacology, Vol 10, Iss 1 (2015) |
| ISSN: | 1991-0088 |
| Popis: | In the present study, effect of retinoic acid ortho-hydroxy aniline amide (RAA), an analog of retinoic acid (RA) was investigated on neurotrophin mediated cell growth and proliferation in hippocampus-derived stem cell clones. The results revealed that retinoic acid ortho-hydroxy aniline amide enhanced neuronal differentiation, increased NeuroD expression and p21 compared to proliferating cells stimulated by FGF-2. Retinoic acid ortho-hydroxy aniline amide treatment prevented decrease in RNA for trkC, enhanced expression of trkB RNA and p75NGFR. Retinoic acid ortho-hydroxy aniline amide treatment for 5 days increased the baseline expression of c- fos mRNA following stimulation with NGF, BDNF, and NT-3. Treatment of cultures with retinoic acid ortho-hydroxy aniline amide for 5 days followed by 5 days in serum alone increased Map2ab-positive cells compared to that of control. Therefore, retinoic acid ortho-hydroxy aniline amide is an effective agent for inducing neuronal differentiation and proliferation and is even more potent than the parent retinoic acid. |
| Databáze: | OpenAIRE |
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