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Kuznetsova H. S., Kuznetsova K. S., Byts T. M., Kuznetsova O. M., Demydov S. M., Povetkina T. N., Gozhenko A. I. Characteristics of endothelial dysfunction in patients with diabetes mellitus. Актуальні проблеми транспортної медицини / Actual problems of transport medicine / 2018;2(52):116-123. ISSN 1818-9385 DOI http://dx.doi.org/10.5281/zenodo.1319073 http://aptm.org.ua CHARACTERISTICS OF ENDOTHELIAL DYSFUNCTION IN PATIENTS WITH DIABETES MELLITUS H. S. Kuznetsova, K. S. Kuznetsova, T. M. Byts, O. M. Kuznetsova, S. M. Demydov, T. N. Povetkina, A. I. Gozhenko State Enterprise Ukrainian Research Institute For Medicine Of Transport, Odessa The role of endothelial dysfunction (ED) in the pathogenesis of diabetes mellitus (DM) in this article was analyzed. In 53 patients with diabetes in the blood plasma, ED markers such as circulating endothelial cells (CECs), their number at different stages of apoptosis, and the concentration of stable NO2- and NO3- metabolites, were determined. The number of CECs in patients with diabetes was more than in 5 times higher than in persons without endocrine and cardiovascular pathology. To assess the complex of structural and functional disorders, the level of endotheliocythemia and the concentration of nitric oxide metabolites were correlated with the glomerular filtration rate (GFR). In patients with diabetes, the NO2- and NO3-level were within the normal range with a tendency to decrease with progression of DKD and ED formation. Key words: endothelial dysfunction, diabetes mellitus, circulating endothelial cells, nitric oxide, diabetic kidney disease, glomerular filtration rate |
