Tips and turns of bacteriophytochrome photoactivation
| Autor: | Heikki Takala, Sebastian Westenhoff, Petra Edlund, Janne A. Ihalainen |
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| Přispěvatelé: | Medicum, Department of Anatomy, Faculty of Medicine, University of Helsinki |
| Rok vydání: | 2020 |
| Předmět: |
Models
Molecular Protein Conformation 116 Chemical sciences HISTIDINE KINASES SIGNAL-TRANSDUCTION fotobiologia bacteriophytochrome photoactivation 010402 general chemistry 01 natural sciences bakteerit Phytochrome B 03 medical and health sciences Protein structure Bacterial Proteins INDUCED PROTON RELEASE PHYTOCHROME-B CRYSTAL-STRUCTURE Physical and Theoretical Chemistry 030304 developmental biology INDUCED CONFORMATIONAL-CHANGES Physics 0303 health sciences RESONANCE RAMAN Mechanism (biology) AGROBACTERIUM-TUMEFACIENS Photochemical Processes Molecular machine 0104 chemical sciences INFRARED FLUORESCENT PROTEINS CHROMOPHORE-BINDING DOMAIN Biophysics 1182 Biochemistry cell and molecular biology valokemia proteiinit Phytochrome Signal Transduction |
| Zdroj: | Photochemical & Photobiological Sciences. 19:1488-1510 |
| ISSN: | 1474-9092 1474-905X |
| DOI: | 10.1039/d0pp00117a |
| Popis: | Phytochromes are ubiquitous photosensor proteins, which control the growth, reproduction and movement in plants, fungi and bacteria. Phytochromes switch between two photophysical states depending on the light conditions. In analogy to molecular machines, light absorption induces a series of structural changes that are transduced from the bilin chromophore, through the protein, and to the output domains. Recent progress towards understanding this structural mechanism of signal transduction has been manifold. We describe this progress with a focus on bacteriophytochromes. We describe the mechanism along three structural tiers, which are the chromophore-binding pocket, the photosensory module, and the output domains. We discuss possible interconnections between the tiers and conclude by presenting future directions and open questions. We hope that this review may serve as a compendium to guide future structural and spectroscopic studies designed to understand structural signaling in phytochromes. |
| Databáze: | OpenAIRE |
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