Lacrimal gland–derived IL-22 regulates IL-17-mediated ocular mucosal inflammation
| Autor: | Sharad K. Mittal, Yong Woo Ji, Sunil K. Chauhan, Hyemi Noh, Hyung Keun Lee, Joon H. Lee, Areum Yeo, Ho Sik Hwang, Yuri Seo, Hye Sun Lee, Eun-Ju Chang |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male 0301 basic medicine Pathology medicine.medical_specialty Immunology Inflammation Acinar Cells Lacrimal gland Eye Article Interleukin 22 Pathogenesis Mice 03 medical and health sciences Immune system Animals Humans Immunology and Allergy Medicine Aged Mice Knockout Transplantation Chimera Mucous Membrane business.industry Interleukins Interleukin-17 Lacrimal Apparatus Middle Aged Mice Inbred C57BL Cross-Sectional Studies 030104 developmental biology medicine.anatomical_structure Mucosal immunology Knockout mouse Th17 Cells Dry Eye Syndromes Female Interleukin 17 medicine.symptom business |
| Zdroj: | Mucosal immunology |
| ISSN: | 1933-0219 |
| DOI: | 10.1038/mi.2016.119 |
| Popis: | Inflammatory damage of mucosal surface of the eye is a hallmark of dry eye disease (DED), and in severe cases can lead to significant discomfort, visual impairment, and blindness. DED is a multifactorial autoimmune disorder with a largely unknown pathogenesis. Using a cross-sectional patient study and a well-characterized murine model of DED, herein we investigated the immunoregulatory function of interleukin-22 (IL-22) in the pathogenesis of DED. We found that IL-22 levels were elevated in lacrimal fluids of DED patients and inversely correlated with severity of disease. Acinar cells of the lacrimal glands, not inflammatory immune cells, are the primary source of IL-22, which suppresses inflammation in ocular surface epithelial cells upon desiccating stress. Moreover, loss of function analyses using IL-22 knock-out mice demonstrated that IL-22 is essential for suppression of ocular surface infiltration of Th17 cells and inhibition of DED induction. Our novel findings elucidate immunoregulatory function of lacrimal gland-derived IL-22 in inhibiting IL-17-mediated ocular surface epitheliopathy in DED thus making IL-22 a new relevant therapeutic target. |
| Databáze: | OpenAIRE |
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