Imbalanced angiogenesis in peripartum cardiomyopathy: diagnostic value of placenta growth factor
| Autor: | Alexandre Mebazaa, Jean-Marie Launay, Najla Akrout, Said Laribi, Marie-France Seronde, Dilly O. C. Anumba, Jane-Lise Samuel, Loubina Fazal, Jamela Sarb, Matthieu Legrand, Kemi Tibazarwa, Lila Bouadma, Corinne Collet, Lydia Deschamps, Etienne Gayat, Karen Sliwa, Mattia Arrigo, Justina Motiejunaite, Philippe Manivet, Alain Cohen Solal, Malha Sadoune |
|---|---|
| Přispěvatelé: | Département d'Anesthésie Réanimation SMUR [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Marqueurs pronostiques et facteurs de régulations des pathologies cardiaques et vasculaires - UFC ( EA 3920) (PCVP / CARDIO), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Université Paris Diderot - Paris 7 (UPD7), Service de biochimie INSERM UMR-S942, Hôpital Lariboisière-APHP, Biomarqueurs CArdioNeuroVASCulaires (BioCANVAS), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de pathologie [CHU Bichat], AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Bichat - Claude Bernard, Hôpital Lariboisière, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Service de Biochimie et de Biologie Moléculaire [AP-HP Hôpital Lariboisière] (Inserm U942), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Lariboisière-Fernand-Widal [APHP], U942, Hop Lariboisiere, AP HP,Dept Biochem, Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Recherche Cardiovasculaire de Lariboisiere, Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Departments of Applied Physics [New Haven], Yale University [New Haven] |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Placental growth factor
medicine.medical_specialty Peripartum cardiomyopathy Angiogenesis [SDV]Life Sciences [q-bio] 030204 cardiovascular system & hematology Gastroenterology 03 medical and health sciences 0302 clinical medicine Pregnancy Internal medicine Peripartum Period medicine Humans In patient 030212 general & internal medicine Placenta Growth Factor ComputingMilieux_MISCELLANEOUS Heart Failure Vascular Endothelial Growth Factor Receptor-1 Neovascularization Pathologic business.industry Peripartum cardiomyopathy (PPCM) General Medicine medicine.disease Endocrinology Heart failure Plasma concentration Relaxin-2 Female Cardiomyopathies Cardiology and Cardiovascular Medicine business |
| Zdroj: | Circulation Journal Circulation Journal, Japanese Circulation Society, 2017, 81 (11), pp.1654-1661. ⟨10.1253/circj.CJ-16-1193⟩ |
| ISSN: | 1346-9843 1347-4820 |
| Popis: | Background: Concentrations of the anti-angiogenic factor soluble fms-like tyrosine kinase-1 (sFlt-1) are altered in peripartum cardiomyopathy (PPCM). In this study we investigated changes in the angiogenesis balance in PPCM. Methods and Results: Plasma concentrations of sFlt-1 and the pro-angiogenic placenta growth factor (PlGF) were determined in patients with PPCM during the post-partum phase (n=83), in healthy women at delivery (n=30), and in patients with acute heart failure (AHF; n=65). Women with cardiac failure prepartum or associated with any form of hypertension, including pre-eclampsia, were excluded. Compared with non-pregnant women, in women with AHF and PPCM, median PlGF concentrations were greater (19 [IQR 16–22] and 98 [IQR 78–126] ng/mL, respectively; P0.94. Median plasma concentrations of the anti-angiogenic factor relaxin-2 were lower in PPCM and AHF (0.3 [IQR 0.3–1.7] and 0.3 [IQR 0.3–1] ng/mL, respectively) compared with normal deliveries (1,807 [IQR 1,101–4,050] ng/mL; P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|