Systemic allergic reaction to initial insulin therapy in a juvenile diabetic. Enhanced blast transformation to insulin
| Autor: | A. Kalpini‐Mavrou, C. Economou‐Mavrou, Th. Thomaidis, E. Roma, C. Dacou‐Voutetakis |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
medicine.medical_specialty
Allergic reaction Adolescent medicine.medical_treatment Lymphocyte Activation Drug Hypersensitivity Precursor cell Internal medicine Diabetes mellitus medicine Juvenile diabetic Humans Insulin Lymphocytes Desensitization (medicine) Blast transformation business.industry Insulin allergy General Medicine medicine.disease Endocrinology Diabetes Mellitus Type 1 Desensitization Immunologic Pediatrics Perinatology and Child Health Immunology Female business |
| Zdroj: | Acta paediatrica Scandinavica. 64(5) |
| ISSN: | 0001-656X |
| Popis: | Dacou-Voutetakis, C. Thomaidis, Th., Roma, E., Katpini-Mavrou, A. and Economou-Mavrou, C. (First Department of Paediatrics, Athens University, Greece). Systemic allergic reaction to initial insulin therapy in a juvenile diabetic. Enhanced blast transformation to insulin. Acta Paediatr Scand, 64: 773, 1975–A 14-year-old girl with recent onset of diabetes developed a severe systemic allergic reaction to beef-pork insulin on the third day of insulin therapy. The same reaction developed following the injection of pork insulin and monocomponent insulin. The patient was induced to tolerate pork insulin by systemic de-sensitization to this insulin over an interval of 6 days. Peripheral blood lymphocytes from the patient cultured in the presence of insulin responded by increased blast cell transformation, as compared with controls, who either had previously presented local allergic reactions to insulin or never had manifested insulin allergy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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