| Přispěvatelé: |
Cento, V, Colagrossi, L, Bossi, I, Armenia, D, Nava, A, Piccinelli, E, Maloberti, A, Inglese, E, Matarazzo, E, DI Ruscio, F, Paba, P, Marcuccilli, F, Perrone, M, Chiricolo, G, Alteri, C, Scaglione, F, Vismara, C, Campisi, D, Fanti, D, Romeo, F, Andreoni, M, Oliva, F, Ceccherini-Silberstein, F, Giannattasio, C, Perno, C |
| Popis: |
Background: Acute coronary syndromes (ACS) are a major cause of morbidity and mortality. As cytomegalovirus (CMV) may contribute to Cardio-Vascular (CV) manifestations, we sought to provide a proof-of-concept for the involvement of coronary and/or systemic CMV-reactivation as a possible ACS trigger. Methods: We prospectively enrolled consecutive patients undergoing a coronary angiography for ACS (acute-cases, N=136), or non-ACS reasons (chronic-cases, N=57). Matched coronary and peripheral blood-samples were processed for quantification of CMV-DNAemia (RT-PCR), CMVIgG/ IgM, and CMV-IgG avidity (ELISA). Peripheral-blood samples from 17 healthy subjects were included as controls. Results: Out of the 193 cases included, 18.1% were aged ≤55 years, 92.5% were Central-European, and 100% immunocompetent. CMV-IgG seroprevalence was 91.7% (95%CI: 87.8-95.6), significantly higher than in healthy-controls (52.9% [95%CI: 29.2-76.5]; p |
