In vitro PHOTODYNAMIC INACTIVATION OF Herpes simplex VIRUS WITH SAPPHYRINS: 22 π-ELECTRON PORPHYRIN-LIKE MACROCYCLES
| Autor: | Joseph T. Newman, Bhaskar G. Maiya, Helen Skiles, J. L. Maithews, Jonathan L. Sessler, M. M. Judy, Mike Cyr, R. L. Boriack, S. T. Nichol |
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| Rok vydání: | 1991 |
| Předmět: |
Radiation-Sensitizing Agents
Liposome Light Chemistry viruses Fluorescence spectrometry General Medicine medicine.disease_cause Biochemistry Fluorescence Porphyrin In vitro chemistry.chemical_compound Herpes simplex virus Viral envelope Liposomes medicine Biophysics Animals Simplexvirus Pyrroles Photosensitizer Physical and Theoretical Chemistry Vero Cells |
| Zdroj: | Photochemistry and Photobiology. 53:101-107 |
| ISSN: | 1751-1097 0031-8655 |
| DOI: | 10.1111/j.1751-1097.1991.tb08473.x |
| Popis: | The photodynamic inactivation of HSV-1, a virus having a membranous envelope, with both a decaalkyl sapphyrin and its dicarboxy-substituted analog was studied. The decaalkyl sapphyrin was as efficient in the inactivation of HSV-1 on a per macrocycle basis as DHE, whereas the efficiency of the dicarboxy-substituted sapphyrin was approximately two orders of magnitude less. Fluorescence studies of sapphyrin's binding to liposomes and VSV suggested that the decaalkylsapphyrin bound monomerically to cholesterol-rich regions of the viral envelope, whereas its charged analog localized in a more polar environment. |
| Databáze: | OpenAIRE |
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