Age-Specific Etiology of Severe Acute Respiratory Infections and Influenza Vaccine Effectivity in Prevention of Hospitalization in Russia, 2018–2019 Season
| Autor: | Olga Afanasieva, Maria Pisareva, Tamila Musaeva, Elizaveta Smorodintseva, Ekaterina Golovacheva, Daria Danilenko, Elena Obraztsova, Elena Dondurey, Dmitry Lioznov, Alexander Shestopalov, Anna Sominina, Andrey Komissarov, Mikhail I. Bakaev, Veronica Timonina, Svetlana Sergeyevna Smirnova, Kirill Stolyarov, Olga Kurskaya, Elena Rozhkova, Dmitry Guzhov, Alexander V. Alimov |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
medicine.medical_specialty Influenza vaccine viruses Population Vaccine Efficacy medicine.disease_cause Virus Antigenic drift Influenza A Virus H1N1 Subtype Internal medicine Intensive care Influenza Human medicine Humans Metapneumovirus Antigenic Drift and Shift Child education Respiratory Tract Infections Vaccine effectiveness Respiratory viruses education.field_of_study business.industry Influenza A Virus H3N2 Subtype Age Factors Infant virus diseases Influenza Hospitalization Influenza Vaccines Child Preschool Etiology Seasons Rhinovirus business Research Article |
| Zdroj: | Journal of Epidemiology and Global Health |
| ISSN: | 2210-6014 |
| Popis: | The expansion and standardization of clinical trials, as well as the use of sensitive and specific molecular diagnostics methods, provide new information on the age-specific roles of influenza and other respiratory viruses in development of severe acute respiratory infections (SARI). Here, we present the results of the multicenter hospital-based study aimed to detect age-specific impact of influenza and other respiratory viruses (ORV). The 2018–2019 influenza season in Russia was characterized by co-circulation of influenza A(H1N1)pdm09 and A(H3N2) virus subtypes which were detected among hospitalized patients with SARI in 19.3% and 16.4%, respectively. RSV dominated among ORV (15.1% of total cases and 26.8% in infants aged ≤ 2 years). The most significant SARI agents in intensive care units were RSV and influenza A(H1N1)pdm09 virus, (37.3% and 25.4%, respectively, of PCR-positive cases). Hyperthermia was the most frequently registered symptom for influenza cases. In contrast, hypoxia, decreased blood O2 concentration, and dyspnea were registered more often in RSV, rhinovirus, and metapneumovirus infection in young children. Influenza vaccine effectiveness (IVE) against hospitalization of patients with PCR-confirmed influenza was evaluated using test-negative case–control design. IVE for children and adults was estimated to be 57.0% and 62.0%, respectively. Subtype specific IVE was higher against influenza A(H1N1)pdm09, compared to influenza A(H3N2) (60.3% and 45.8%, respectively). This correlates with delayed antigenic drift of the influenza A(H1N1)pdm09 virus and genetic heterogeneity of the influenza A(H3N2) population. These studies demonstrate the need to improve seasonal influenza prevention and control in all countries as states by the WHO Global Influenza Strategy for 2019–2030 initiative. |
| Databáze: | OpenAIRE |
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