Design, synthesis and SAR of a novel series of heterocyclic phenylpropanoic acids as GPR120 agonists

Autor:	Austin Bell, Hong Hua, Wen Yan, Chaozhong Cai, Celia Jenkinson, Peter Haug, Wall Mark, Yuanping Wang, Imad Nashashibi, Xuqing Zhang, Arthur T. Suckow, Michael P. Winters, James N. Leonard, Michele Wells, Joseph Gunnet, William V. Murray, Zhihua Sui, Jingyuan Ma, James C. Lanter, Wilma Clapper, Aaron Novack
Rok vydání:	2017
Předmět:	Blood Glucose 0301 basic medicine Clinical Biochemistry Biological Availability Pharmaceutical Science Phenylpropanoic acid 01 natural sciences Biochemistry Receptors G-Protein-Coupled Structure-Activity Relationship 03 medical and health sciences chemistry.chemical_compound Heterocyclic Compounds In vivo Drug Discovery Animals Humans Hypoglycemic Agents Organic chemistry Molecular Biology Phenylpropionates 010405 organic chemistry Chemistry Organic Chemistry GPR120 0104 chemical sciences Bioavailability Mice Inbred C57BL HEK293 Cells 030104 developmental biology Diabetes Mellitus Type 2 Design synthesis Drug Design Molecular Medicine
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 27:3272-3278
ISSN:	0960-894X
Popis:	A novel series of 5-membered heterocycle-containing phenylpropanoic acid derivatives was discovered as potent GPR120 agonists with low clearance, high oral bioavailability and in vivo antidiabetic activity in rodents.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c99a9954f694ac0a6035dcb18ac83bf https://doi.org/10.1016/j.bmcl.2017.06.028 Zobrazit plný text záznamu Full Text from ScienceDirect