Sulfur sequestration promotes multicellularity during nutrient limitation
| Autor: | Erika L. Pearce, Yaarub Musa, Beth Kelly, Thomas Becker, Lea J. Flachsmann, Jonathan D. Curtis, Gustavo E. Carrizo, Gerhard Mittler, David E. Sanin, Chantal Priesnitz, Joy Edwards-Hicks, Joerg M. Buescher, Michal A. Stanczak |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Iron-Sulfur Proteins
Cellular differentiation Cell Respiration macromolecular substances Cell fate determination Dictyostelium discoideum Article Antioxidants 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Dictyostelium Cysteine 030304 developmental biology Cell Aggregation Cell Proliferation chemistry.chemical_classification 0303 health sciences Reactive oxygen species Multidisciplinary biology Cell Differentiation Metabolism Glutathione Nutrients biology.organism_classification Cell biology Mitochondria Oxygen Multicellular organism chemistry Eukaryote Amino Acids Essential Food Deprivation Reactive Oxygen Species 030217 neurology & neurosurgery Sulfur Signal Transduction |
| Zdroj: | Nature |
| Popis: | The behaviour of Dictyostelium discoideum depends on nutrients1. When sufficient food is present these amoebae exist in a unicellular state, but upon starvation they aggregate into a multicellular organism2,3. This biology makes D. discoideum an ideal model for investigating how fundamental metabolism commands cell differentiation and function. Here we show that reactive oxygen species—generated as a consequence of nutrient limitation—lead to the sequestration of cysteine in the antioxidant glutathione. This sequestration limits the use of the sulfur atom of cysteine in processes that contribute to mitochondrial metabolism and cellular proliferation, such as protein translation and the activity of enzymes that contain an iron–sulfur cluster. The regulated sequestration of sulfur maintains D. discoideum in a nonproliferating state that paves the way for multicellular development. This mechanism of signalling through reactive oxygen species highlights oxygen and sulfur as simple signalling molecules that dictate cell fate in an early eukaryote, with implications for responses to nutrient fluctuations in multicellular eukaryotes. Depriving unicellular Dictyostelium discoideum of nutrients generates reactive oxygen species that sequester cysteine within glutathione, which maintains this amoeba in a nonproliferating state that promotes aggregation into a multicellular organism. |
| Databáze: | OpenAIRE |
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