A nuclear magnetic resonance investigation of the upper airways in ferrets. i. effects of histamine and methacholine
| Autor: | Marise E. Alexander, Thomas A. Neubecker, Jeanne K. C. Barnett, Carol M. Goecke, Nicholas V. Reo |
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| Rok vydání: | 1992 |
| Předmět: |
Male
Magnetic Resonance Spectroscopy Respiratory System Provocation test Turbinates Spin–spin relaxation chemistry.chemical_compound Nuclear magnetic resonance Carnivora medicine Animals Radiology Nuclear Medicine and imaging Administration Intranasal Methacholine Chloride biology Fissipedia Ferrets biology.organism_classification Magnetic Resonance Imaging Intensity (physics) chemistry Methacholine Nasal administration Histamine medicine.drug |
| Zdroj: | Magnetic Resonance in Medicine. 27:21-33 |
| ISSN: | 1522-2594 0740-3194 |
| DOI: | 10.1002/mrm.1910270104 |
| Popis: | Alterations induced in the upper airways of ferrets by intranasal provocation with methacholine (MC) and histamine (HS) were monitored using proton magnetic resonance imaging (MRI) and spin-spin relaxation rate (R2) measurements. Both MC and HS cause a significant increase in the MRI signal intensity and a decrease in R2 in the nasal turbinates. A dose-dependent response is observed for 20 to 315 nmol of HS, with a maximum increase in intensity of ca. 50% occurring above 80 nmol. A single unilateral challenge with MC yields a 62 +/- 3% increase in intensity. Control animals (saline-treated) show little change in image intensity. MC and HS cause decreases in the proton R2 by -27.0 +/- 5.5% and -17.2 +/- 4.3%, respectively. These data are indicative of an accumulation of fluid in the nasal airways. MRI provides an effective means to monitor changes in the nasal airways which occur as a result of pharmacological treatment. |
| Databáze: | OpenAIRE |
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