Inhibitory Effect of Pancreatic Secretin on Gastric Secretion
| Autor: | Lester R. Dragstedt, Jose Delgadillo Guerrero, Thomas S. Nelsen, Herbert B. Greenlee, Abdul Latif El-Bedri, Enrique H. Longhi |
|---|---|
| Rok vydání: | 1957 |
| Předmět: |
medicine.medical_specialty
Gastric Juice business.industry digestive oral and skin physiology Pancreatic secretin Heidenhain pouch medicine.disease digestive system digestive system diseases Gastric secretion Endocrinology Secretin Pancreatic fistula Physiology (medical) Internal medicine medicine Digestion Secretion business Inhibitory effect hormones hormone substitutes and hormone antagonists |
| Zdroj: | American Journal of Physiology-Legacy Content. 190:396-402 |
| ISSN: | 0002-9513 |
| DOI: | 10.1152/ajplegacy.1957.190.3.396 |
| Popis: | In dogs prepared with both a vagus denervated Heidenhain pouch and a total pancreatic fistula, the intravenous injection of pancreatic secretin (Lilly) produced a profuse secretion of pancreatic juice and a simultaneous marked inhibition of gastric secretion. In dogs prepared with an isolated antrum pouch and a Heidenhain pouch the gastric secretion induced by the instillation of food in the antrum pouch was completely inhibited by the intravenous injection of pancreatic secretin. On the other hand, the intravenous injection of pancreatic secretin had little or no effect on the secretion of gastric juice produced by insulin hypoglycemia or by the injection of histamine. It is suggested that pancreatic secretin may represent the mechanism by means of which acid food in the duodenum inhibits gastric secretion. It is probable that this inhibition is caused by prevention of gastrin release from the antrum rather than to a depressant effect on the parietal cells. |
| Databáze: | OpenAIRE |
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