The effect of intrathecal bupivacaine/morphine on quality of recovery in robot-assisted radical prostatectomy: a randomised controlled trial
| Autor: | Elisabeth J. Ruijgrok, Aart Jan W. Teunissen, Mark V. Koning, J. S. H. A. Koopman, Robert Jan Stolker, R. de Vlieger, M. Gan, J. C. de Graaff |
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| Přispěvatelé: | Anesthesiology, Pharmacy |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
robot‐assisted radical prostatectomy medicine.medical_treatment Sedation Analgesic Anesthesia General Anesthesia Spinal Loading dose law.invention Postoperative Complications Robotic Surgical Procedures Randomized controlled trial law Anesthesia Conduction Surveys and Questionnaires quality of recovery medicine Humans General anaesthesia Postoperative Period Anesthetics Local Injections Spinal Aged Pain Measurement Bupivacaine Prostatectomy Morphine business.industry Pruritus Original Articles postoperative analgesia Robotics Middle Aged intrathecal morphine Treatment Outcome Anesthesiology and Pain Medicine Anesthesia Anesthesia Recovery Period Original Article medicine.symptom business medicine.drug |
| Zdroj: | Anaesthesia, 75(5), 599-608. Wiley-Blackwell Publishing Ltd Anaesthesia |
| ISSN: | 0003-2409 |
| Popis: | Summary Robot‐assisted radical prostatectomy causes discomfort in the immediate postoperative period. This randomised controlled trial investigated if intrathecal bupivacaine/morphine, in addition to general anaesthesia, could be beneficial for the postoperative quality of recovery. One hundred and fifty‐five patients were randomly allocated to an intervention group that received intrathecal 12.5 mg bupivacaine/300 μg morphine (20% dose reduction in patients > 75 years) or a control group receiving a subcutaneous sham injection and an intravenous loading dose of 0.1 mg.kg−1 morphine. Both groups received standardised general anaesthesia and the same postoperative analgesic regimen. The primary outcome was a decrease in the Quality of Recovery‐15 (QoR‐15) questionnaire score on postoperative day 1. The intervention group (n = 76) had less reduction in QoR‐15 on postoperative day 1; median (IQR [range]) 10% (1–8 [−60% to 50%]) vs. 13% (5–24 [−6% to 50%]), p = 0.019, and used less morphine during the admission; 2 mg (1–7 [0–41 mg]) vs. 15 mg (12–20 [8–61 mg]), p |
| Databáze: | OpenAIRE |
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