Elevated cerebrospinal fluid β2-microglobulin levels in patients with neuromyelitis optica spectrum disorders
| Autor: | Li Yang, Sheng-Hui Chang, Li-Sha Sun, Nan Wang, Ming-Qi Liu, Chun-Sheng Yang, Yuan Qi, Chen-Na Huang, Qiu-Xia Zhang, Lin-Jie Zhang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Pathology
medicine.medical_specialty Multiple Sclerosis Inflammation Disease 03 medical and health sciences Leukocyte Count 0302 clinical medicine Cerebrospinal fluid medicine Humans In patient 030212 general & internal medicine Aquaporin 4 Beta-2 microglobulin business.industry Multiple sclerosis Neuromyelitis Optica General Medicine medicine.disease Neurology Neuromyelitis Optica Spectrum Disorders Weak association Neurology (clinical) medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Multiple sclerosis and related disorders. 49 |
| ISSN: | 2211-0356 |
| Popis: | Cerebrospinal fluid (CSF) β2-microglobulin (β2-MG) levels elevated in patients with multiple sclerosis (MS). We examined the levels of β2-MG in serum and cerebrospinal fluid (CSF) from 46 patients with neuromyelitis optica spectrum disorders (NMOSD), in serum from 21 healthy controls (HC), in CSF from 25 disease controls with non-inflammatory neurological diseases (NIND) with normal CSF results. CSF β2-MG levels were significantly higher in patients with NMOSD than controls and with weak association with the number of white blood cells, protein and lactate levels in CSF. CSF β2-MG is thus one more, non-specific indicator of inflammation in NMOSD. |
| Databáze: | OpenAIRE |
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