Activin/Nodal signals mediate the ventral expression of myf-5 in Xenopus gastrula embryos
| Autor: | Yuguang Chen, Ying Chen, Gufa Lin, Rui-Ying Hu, Xiaoyan Ding |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
medicine.medical_specialty
animal structures Nodal Protein Xenopus Biophysics Muscle Proteins Xenopus Proteins Biochemistry Transforming Growth Factor beta Internal medicine medicine Animals SMAD binding Promoter Regions Genetic Molecular Biology Activin type 2 receptors DNA Primers Regulator gene Base Sequence biology Myogenesis Gene Expression Regulation Developmental Embryo Gastrula Cell Biology biology.organism_classification Activins Cell biology DNA-Binding Proteins Gastrulation Endocrinology embryonic structures Trans-Activators Female Myogenic Regulatory Factor 5 NODAL |
| Zdroj: | Biochemical and Biophysical Research Communications. 310:121-127 |
| ISSN: | 0006-291X |
| DOI: | 10.1016/j.bbrc.2003.08.127 |
| Popis: | Expression of myf-5, a key component of myogenic regulatory genes, expands into the ventral marginal zone during Xenopus gastrulation after the dorsal activation takes place. Little is known about how this dynamic expression pattern occurs. Here, we provide evidences to suggest that Activin/Nodal signals participate in the regulation of ventral expression of Xmyf-5 in gastrula embryos. Two Smad binding elements (SBEs) within the Xenopus myf-5 promoter can specifically interact with Smad4 protein. Furthermore, we demonstrate that the two SBEs are both indispensable for conferring responsiveness to Activin/Nodal signals and to ventral expression of myf-5 in Xenopus gastrula embryos. |
| Databáze: | OpenAIRE |
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