Synthesis of novel fused acenaphtopyrimidine hybrid, its photophysical properties and HSA interaction

Autor:	Ergin Yalçın
Přispěvatelé:	Mühendislik ve Doğa Bilimleri Fakültesi -- Mühendislik Temel Bilimleri Bölümü, Yalçın, Ergin
Rok vydání:	2021
Předmět:	Fused heterocyclic compounds Human serum-albumin Chemistry Van Der Waals Forces Dna/Hsa-binding General Chemistry HSA interaction Combinatorial chemistry Pepsin A Photophysical properties Solvatochromism Acenaphtopyrimidine derivatives Human Serum Albumin
Zdroj:	Supramolecular Chemistry. 33:222-230
ISSN:	1029-0478 1061-0278
DOI:	10.1080/10610278.2021.1975710
Popis:	A facile and versatile procedure for the synthesis of novel functionalised 10-(1H-indol-3-yl)acenaphtho[1,2-d]pyrimidin-8-amine (compound 4) has been described. The novel intermediate enone (3) and pyrimidine derivatives (4) were characterised by using FT-IR, NMR and MS. Moreover, the photophysical properties of compound 4 and its interaction with HSA (Human Serum Albumin) have been investigated by means of photometric and fluorimetric titration. Compound 4 showed the increase in fluorescence and hypsochromic shift of its maximum upon the addition of HSA that interaction is supported by molecular docking. Overall, Compound 4 has promising affinity towards HSA which was not previously reported for any fused acenaphtenone-pyrimidine hybrid analogues.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c8f2785ba8e6a4b00b772870a751d44 https://doi.org/10.1080/10610278.2021.1975710 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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