Scaffolding the attention-deficit/hyperactivity disorder brain using transcranial direct current and random noise stimulation: A randomized controlled trial
| Autor: | Mor Nahum, Roi Cohen Kadosh, Ornella Dakwar-Kawar, Ephraim S. Grossman, Itai Berger |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Prefrontal Cortex Audiology Transcranial Direct Current Stimulation 050105 experimental psychology law.invention Executive Function 03 medical and health sciences 0302 clinical medicine Double-Blind Method Randomized controlled trial law Physiology (medical) mental disorders medicine Humans Attention deficit hyperactivity disorder 0501 psychology and cognitive sciences Child Neurostimulation Cross-Over Studies Transcranial direct-current stimulation business.industry Working memory 05 social sciences Cognition medicine.disease Sensory Systems Cognitive training Acoustic Stimulation Neurology Attention Deficit Disorder with Hyperactivity Brain stimulation Female Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | Clinical Neurophysiology. 132:699-707 |
| ISSN: | 1388-2457 |
| DOI: | 10.1016/j.clinph.2021.01.005 |
| Popis: | Objective Improving symptomology and cognitive deficits in neurodevelopmental disorders is a crucial challenge. We examined whether neurostimulation protocols, which have been shown to yield long-term effects when combined with cognitive training, could benefit children with Attention-deficit/hyperactivity-disorder (ADHD), the most common neurodevelopmental disorder in childhood. Methods We used a randomized double-blind active-controlled crossover study of 19 unmedicated children with ADHD, who received either anodal transcranial direct current stimulation (tDCS) over the left dorsolateral prefrontal cortex (dlPFC) or random noise stimulation (tRNS) over the bilateral dlPFC, while completing executive functions training. Results For our primary outcome, tRNS yielded a clinical improvement as indicated by the reduced ADHD rating-scale score from baseline, and in comparison to the changes observed in tDCS. The effect of brain stimulation one week after completion of treatment yielded further improvement, suggesting a neuroplasticity-related effect. Finally, tRNS improved working memory compared to tDCS, and a larger tRNS effect on ADHD rating-scale was predicted for those who showed the greatest improvement in working memory. Conclusions We found that our intervention can have a lasting effect, rather than a merely immediate effect as was shown for in previous medical interventions in ADHD. Significance Our results provide a promising direction toward a novel intervention in ADHD. |
| Databáze: | OpenAIRE |
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