Insulin-like growth factor I preserves host lean tissue mass in cancer cachexia
| Autor: | Craig S. Rock, Stephen F. Lowry, Lyle L. Moldawer, Eng-Hen Ng, L. Stiaino-Coico, D. D. Lazarus |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Blood Glucose
medicine.medical_specialty Cachexia Physiology medicine.medical_treatment Population Biology Weight Gain Eating Gastrocnemius muscle Insulin-like growth factor Physiology (medical) Internal medicine medicine Animals Insulin-Like Growth Factor I education Saline Analysis of Variance education.field_of_study Ploidies Muscles Growth factor Cell Cycle Proteins Skeletal muscle DNA DNA Neoplasm Flow Cytometry medicine.disease Rats Inbred F344 Recombinant Proteins Rats Endocrinology medicine.anatomical_structure RNA Sarcoma Experimental medicine.symptom Weight gain |
| Zdroj: | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 262:R426-R431 |
| ISSN: | 1522-1490 0363-6119 |
| DOI: | 10.1152/ajpregu.1992.262.3.r426 |
| Popis: | Insulin-like growth factor I (IGF-I) has been implicated in the regulation and maintenance of skeletal muscle protein balance and thus may be of potential benefit in attenuating the cancer-cachectic process. To examine this hypothesis, 47 sham or tumor-implanted Fischer 344 rats were randomized to receive either continuous subcutaneous IGF-I (220 or 400 micrograms/day) or saline as control. In the tumor-bearing (TB) population, IGF-I-treated groups showed a dose-dependent increase in host weight gain (P less than 0.05), final carcass weight (P less than 0.05), and gastrocnemius muscle weights (P less than 0.05) and protein contents (0.50 +/- 0.02, 0.40 +/- 0.01, and 0.52 +/- 0.03 g/100 g host wt, for non-TB saline, TB saline, and TB 400 mg IGF-I groups, respectively; P less than 0.01, IGF-I vs. saline). Similar increases in muscle RNA and DNA contents (P less than 0.01) were induced by IGF-I treatment (P less than 0.05). IGF-I treatment in this rat sarcoma model significantly reduced the proportion of aneuploid cells in the tumor (aneuploid-to-diploid ratio: TB saline 1.1 +/- 0.2 vs. TB IGF-I 0.5 +/- 0.1; P less than 0.05). IGF-I treatment attenuated host muscle protein and lean tissue depletion without stimulation of tumor growth. The tumor aneuploid population was reduced in response to IGF-I treatment. Thus IGF-I may be a potential therapeutic agent in cancer-induced cachexia. |
| Databáze: | OpenAIRE |
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