Respiratory Syncytial Virus Infection in Navajo and White Mountain Apache Children
| Autor: | Raymond Reid, Robert Weatherholtz, Mathuram Santosham, Katherine L. O'Brien, Janné Croll, Jane Oski, Ruth A. Karron, Jana Bockova |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Pediatrics
medicine.medical_specialty Population Respiratory Syncytial Virus Infections Disease Severity of Illness Index Risk Factors Severity of illness medicine Humans Prospective Studies Respiratory system Prospective cohort study education Univariate analysis education.field_of_study business.industry Incidence (epidemiology) Infant medicine.disease United States Hospitalization Logistic Models Bronchiolitis Population Surveillance Pediatrics Perinatology and Child Health Indians North American business |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1098-4275 0031-4005 |
| DOI: | 10.1542/peds.110.2.e20 |
| Popis: | Objective. The hospitalization rate for bronchiolitis of any cause among US children younger than 1 year is estimated at 31.2 per 1000. No data exist on respiratory syncytial virus (RSV)-specific hospitalization rates among high-risk Native Americans other than Alaska Natives, for whom the incidence of RSV hospitalization was estimated at 150 per 1000 among infants younger than 1 year. We aimed to estimate RSV hospitalization rates among Navajo and White Mountain Apache children younger than 2 years. Methods. We conducted prospective population-level hospital-based surveillance to determine RSV hospitalization rates among Navajo and White Mountain Apache children younger than 2 years. From 1997 to 2000, all children who were admitted for acute lower respiratory tract infection between October 1 and March 31 had a nasopharyngeal aspirate obtained and tested for RSV by commercial enzyme immunoassay kits. We reviewed charts of children who tested positive for RSV antigen to determine disease severity. Results. During 3 RSV seasons (1997–2000), 51.3% of 1837 admissions for acute lower respiratory tract infection among children younger than 2 years were attributed to RSV infection. The overall seasonal RSV hospitalization rate among children younger than 2 years was 63.6 per 1000 and 91.3 per 1000 among children younger than 1 year. In a univariate analysis, predictors of severity included age Conclusions. Navajo and White Mountain Apache children are at high risk for RSV disease requiring hospitalization. A lower threshold for hospitalization or underlying chronic conditions that predispose to severe RSV disease do not seem to explain high RSV hospitalization rates in this population. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|