Evaluation of Wound Healing Activity of Salvianolic Acid B on In Vitro Experimental Model
| Autor: | Anna Szewczyk, Urszula Szwedowicz, Anna Choromanska, Krzysztof Gołąb |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
collagen Modern medicine cell migration QH301-705.5 Cell Survival Danshen Gingiva Stimulation Pharmacology Catalysis Article Cell Line salvianolic acid B Inorganic Chemistry 03 medical and health sciences Collagen Type III 0302 clinical medicine Cell Movement Medicine Humans Viability assay Biology (General) Physical and Theoretical Chemistry QD1-999 Molecular Biology Spectroscopy Benzofurans Cell Proliferation Wound Healing business.industry Organic Chemistry Cell migration General Medicine Fibroblasts Models Theoretical In vitro Computer Science Applications Chemistry 030104 developmental biology Cell culture 030220 oncology & carcinogenesis Wound healing business |
| Zdroj: | International Journal of Molecular Sciences Volume 22 Issue 14 International Journal of Molecular Sciences, Vol 22, Iss 7728, p 7728 (2021) |
| ISSN: | 1422-0067 |
| Popis: | Despite a wide range of bactericides and antiseptics, the treatment of chronic or complicated wounds is still a major challenge for modern medicine. Topical medications are the most sought-after new agents for use as treatment. The therapeutic concentration of their active substances is easy to achieve with the lowest possible burden on the patient’s body. This study assesses the effect of salvianolic acid B (Sal B) on the proliferation, migration, and production of collagen type III by fibroblasts, which are the most important processes in wound healing. The study was conducted on human gingival fibroblasts obtained from primary cell culture. The results showed that Sal B at a dose of 75 µg/mL increases the cell viability with significant stimulation of the cell migration as demonstrated in the wound healing assay, as well as an increase in the expression of collagen type III, which has great importance in the initial stages of wound scarring. The results obtained in the conducted studies and previous scientific reports on the antibacterial properties and low toxicity of Sal B indicate its high potential in wound healing. |
| Databáze: | OpenAIRE |
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