Efficacy of L-arginine for preventing preeclampsia in high-risk pregnancies: A double-blind, randomized, clinical trial

Autor:	García Benavides L, Totsuka Sutto Se, Camarena Pulido Ee, Pascoe Gonzalez S, Madrigal Saray Aj, Panduro Barón Jg, García Padilla Fe
Rok vydání:	2016
Předmět:	Gestational hypertension Adult medicine.medical_specialty Adolescent Birth weight Pregnancy High-Risk Blood Pressure 030204 cardiovascular system & hematology Placebo Arginine law.invention Preeclampsia 03 medical and health sciences Young Adult 0302 clinical medicine Randomized controlled trial Double-Blind Method Pre-Eclampsia law Pregnancy Internal Medicine medicine Humans reproductive and urinary physiology 030219 obstetrics & reproductive medicine Eclampsia Obstetrics business.industry Obstetrics and Gynecology medicine.disease female genital diseases and pregnancy complications Clinical trial Treatment Outcome Female business
Zdroj:	Hypertension in pregnancy. 35(2)
ISSN:	1525-6065
Popis:	Objective: This study aimed to estimate the effectiveness of L-arginine for preventing preeclampsia in high-risk pregnancy. Methods: We performed a randomized, double-blind, placebo-controlled, clinical trial in patients with high-risk factors for preeclampsia. Fifty subjects received L-arginine, beginning from the 20th week of gestation. An additional 50 patients received homologated placebo. Results: The placebo group had a higher number of cases of preeclampsia (11/47) compared with the L-arginine group (3/49, P = 0.01). Birth weight was higher in the L-arginine group and there was a smaller number of preterm births (P = 0.03). Conclusion: L-arginine is effective for preventing preeclampsia.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c8365546ad462724d2d8e0380f1ab9b https://pubmed.ncbi.nlm.nih.gov/27003763 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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