Alteration of endogenous antioxidant enzymes in naturally occurring hypertrophic cardiomyopathy
| Autor: | Redman Chu, Simon J.T. Mao, Chih-Sheng Lin, Yu Lin Sun, Chang Yeu Liu, Mu-Chiou Huang, Ling Chu Chang, San-Yuan Huang, Jyh Hung Lin, Ping Cheng Yang, Yung Tsung Chiu |
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| Rok vydání: | 1998 |
| Předmět: |
medicine.medical_specialty
Antioxidant Swine medicine.medical_treatment Clinical Biochemistry Ischemia medicine.disease_cause Biochemistry Thiobarbituric Acid Reactive Substances Antioxidants Superoxide dismutase Internal medicine Genetics medicine Animals cardiovascular diseases Molecular Biology chemistry.chemical_classification Glutathione Peroxidase biology Superoxide Dismutase Glutathione peroxidase Myocardium Body Weight Hypertrophic cardiomyopathy Cell Biology Cardiomyopathy Hypertrophic medicine.disease Catalase Disease Models Animal Endocrinology chemistry cardiovascular system biology.protein Dismutase Lipid Peroxidation Oxidative stress |
| Zdroj: | Biochemistry and molecular biology international. 43(6) |
| ISSN: | 1039-9712 |
| Popis: | We have recently developed a porcine model with naturally occurring hypertrophic cardiomyopathy (HCM). Similar to humans, occluded intramural coronary artery and damaged mitochondria are frequently observed in these animals in which the disease is thought to be associated with the local ischemia of myocardium. In view of antioxidant functions involved in the ischemic injury, we measured the expression of endogenous antioxidant enzymes in the tissues with and without HCM. The results showed a significant increase of Cu,Zn-superoxide dismutase (SOD), but not Mn-SOD, and decrease of catalase (CAT) activities in the various areas of HCM hearts. It was demonstrated that SOD/CAT ratios in the HCM hearts were significantly higher than those in normals and were found to be dramatically correlated with the severity of cardiac hypertrophy. The altered SOD/CAT ratio was also consistent with increase in lipid damage. We hypothesize that the elevated SOD combined with an inadequate amount of H2O2 scavenging enzyme may lead HCM heart at oxidative stress risk. However, the pathogenic role of imbalanced antioxidant enzyme needs to be further explored. |
| Databáze: | OpenAIRE |
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