Comparison of subsequent infusion hypersensitivity reactions to paclitaxel using two different infusion strategies
| Autor: | Stephanie Folan, Michael Berger, Junan Li, Kristen Nymberg, Kyle Zanath, Craig A. Vargo, Jeffrey VanDeusen |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Paclitaxel Drug Hypersensitivity 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Medicine Humans In patient 030212 general & internal medicine Asthma Aged Retrospective Studies business.industry Incidence (epidemiology) Incidence Dosing regimen Retrospective cohort study Middle Aged Rescue medication medicine.disease Hypersensitivity reaction Oncology chemistry 030220 oncology & carcinogenesis Anesthesia Female business |
| Zdroj: | Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer. 29(8) |
| ISSN: | 1433-7339 |
| Popis: | The purpose of this study was to compare the incidence of rescue medication utilization with up to 3 subsequent doses of paclitaxel in patients who underwent an infusion rate escalation versus those who continued on the standard infusion rate after experiencing an initial paclitaxel infusion hypersensitivity reaction (HSR) requiring rescue medications. A retrospective, single-center review was conducted on patients who experienced a paclitaxel infusion HSR requiring rescue medications to their first or second lifetime dose of paclitaxel. A total of 99 patients were included for analysis, and from this group, 22 patients were continued on the standard infusion rate, while 77 patients were changed to an infusion rate escalation. The rate of subsequent rescue medication utilization was 5% in patients who were continued at the standard infusion rate versus 23% in patients who were changed to an infusion rate escalation (p = 0.064). The incidence of subsequent rescue medication utilization was unrelated to disease stage (p = 0.39), the paclitaxel dosing regimen (p = 0.99), or a diagnosis of asthma (p = 0.99). This single-center, retrospective study suggests that while not statistically significant, there was a potentially clinically meaningful increase in the rate of subsequent rescue medication utilization in patients who were changed to an infusion rate escalation compared to those who continued on the same standard infusion rate after experiencing an initial HSR to paclitaxel. |
| Databáze: | OpenAIRE |
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