The Effect of Palm Oil-Fried Street Kokor on Liver and Kidney Biomarkers of Swiss Albino Mice
Autor: | Tigist Mateos, Hailemariam Amsalu, Minale Fekadie, Gesese Bogale, Tesaka Wondimnew |
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Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Article Subject Physiology Aspartate transaminase QD415-436 Biochemistry 03 medical and health sciences chemistry.chemical_compound 0404 agricultural biotechnology Palm oil QP1-981 Medicine Creatinine Kidney 030109 nutrition & dietetics biology business.industry Liver and kidney 04 agricultural and veterinary sciences 040401 food science medicine.anatomical_structure Alanine transaminase chemistry biology.protein Urea business Palm Research Article |
Zdroj: | Journal of Lipids, Vol 2020 (2020) Journal of Lipids |
ISSN: | 2090-3049 2090-3030 |
DOI: | 10.1155/2020/8819749 |
Popis: | Background. Foods fried with oils at streets contain many harmful substances for health. Locally fried foods are consumed commonly in our society, yet their health effect is not studied. Objective. To assess the effect of palm oil-fried street kokor on liver and kidney biomarkers of Swiss Albino mice. Methods. Thirty-two male and female Swiss Albino mice with the age of 10-12 weeks old were divided randomly into four groups of eight members with equal male and female subgroups. The control group (group I) received only a standard pellet, and the experimental groups (group II, group III, and group IV) received 10%, 20%, and 30% kokor of their daily food consumption, respectively. At the end of the 6th week, they were sacrificed by thoracoabdominal incision after anesthetizing by diethyl ether. Blood was taken from each mouse by cardiac puncture and analyzed for liver and kidney function tests. Result. The serum levels of liver damage biomarkers (alanine transaminase (ALT) and aspartate transaminase (AST)) and kidney damage biomarkers (urea and creatinine) of experimental groups were increased significantly relative to the control groups ( P < 0.05 ). Level of biochemical profiles increased as the dose of kokor increased. Conclusions. Palm oil-fried street kokor damaged the liver and kidney of the mice, and the damage was exacerbated as the dose of kokor increased. |
Databáze: | OpenAIRE |
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