Dissecting diverse functions of NMDA receptors by structural biology
| Autor: | Jue Xiang Wang, Hiro Furukawa |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0303 health sciences
Protein domain Alternative splicing Biology Crystallography X-Ray Receptors N-Methyl-D-Aspartate Article 03 medical and health sciences 0302 clinical medicine Membrane protein Structural biology Protein Domains Structural Biology Extracellular NMDA receptor Animals Humans Receptor Extracellular Space Molecular Biology Neuroscience 030217 neurology & neurosurgery Ion channel 030304 developmental biology |
| Zdroj: | Current opinion in structural biology. 54 |
| ISSN: | 1879-033X |
| Popis: | N-Methyl-d-aspartate receptors (NMDARs) are glutamate-gated ion channels, which are critically involved in brain development, learning and memory, cognition, as well as a number of neurological diseases and disorders. Structural biology of NMDARs has been challenging due to technical difficulties associated with assembling a number of different membrane protein subunits. Here, we review historical X-ray crystallographic studies on isolated extracellular domains, which are still the most effective mean to delineate compound binding modes, as well as the most recent studies using electron cryo-microscopy (cryo-EM). A number of NMDAR structures accumulated over the past 15 years provide insights into the hetero-tetrameric assembly pattern, pharmacological specificities elicited by subtypes and alternative splicing, and potential patterns of conformational dynamics; however, many more important unanswered questions remain. |
| Databáze: | OpenAIRE |
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