Peculiarity of recovery of the hypothalamic-pituitary-gonadal (hpg) axis, in men after using androgenic anabolic steroids
| Autor: | Yury N Fedotov, V A Makarin, Mykola P. Lykhonosov, Alina Y. Babenko |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty Anabolism Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Hypothalamic–pituitary–gonadal axis 03 medical and health sciences 0302 clinical medicine Internal medicine Humans Medicine Testosterone Prospective Studies Prospective cohort study Testosterone Congeners business.industry Hypogonadism Luteinizing Hormone Prolactin Exact test Endocrinology 030220 oncology & carcinogenesis business Luteinizing hormone Hormone |
| Zdroj: | Problems of Endocrinology. 66:104-112 |
| ISSN: | 2308-1430 0375-9660 |
| DOI: | 10.14341/probl12223 |
| Popis: | BACKGROUND: Spontaneous recovery of the hypothalamic–pituitary–gonadal (HPG) axis after cessation of testosterone replacement therapy or after male contraception may take up to 24 months. There is insufficient data on the duration of recovery of HPG axis after abuse of androgenic anabolic steroids (AAS). AAS users use post-cycle therapy (PCT) to restore HPG axis, the effectiveness of which is unknown and needs further investigation. AIMS: To evaluate the recovery of HPG axis in men, AAS users, after a 3-month of cessation of their use and after PCT. METHODS: An observational, single-center, prospective, sampling, open, uncontrolled study was conducted among male AAS users. While using of AAS and 3 months after the refusal of their administration and PCT, the clinical symptoms of hypogonadism were evaluated, luteinizing hormone (LH), follicle-stimulating hormone (FSH), total testosterone (Tt), prolactin, estradiol, inhibin B, thyroid-stimulating hormone (TSH) were determined. The scheme of rehabilitation therapy was the same and did not change throughout the study. Recovery criteria: Tt >3.4 ng/ml and LH >1.24 mIU/ml. The study was conducted from January to August 2019. Fisher’s exact test, Mann-Whitney U-test, and Spearman’s rank correlation coefficient were used. The differences were considered statistically significant at p |
| Databáze: | OpenAIRE |
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