Ca2+-activated K+ channels involved in duodenal dismotility induced by ethanol
| Autor: | M. A. Plaza, M. D. Murillo, Laura Grasa, Diego Santos Fagundes, M. P. Arruebo |
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| Rok vydání: | 2007 |
| Předmět: |
Male
Charybdotoxin Duodenum In Vitro Techniques Potassium Channels Calcium-Activated chemistry.chemical_compound Potassium Channel Blockers medicine Animals K channels Ethanol Chemistry Central Nervous System Depressants Muscle Smooth Potassium channel blocker General Medicine Acetylcholine Small intestine Solutions medicine.anatomical_structure Biochemistry Data Interpretation Statistical Biophysics Rabbits medicine.symptom Gastrointestinal Motility Peptides Muscle Contraction medicine.drug Muscle contraction |
| Zdroj: | Alcohol and Alcoholism. 42:291-295 |
| ISSN: | 1464-3502 0735-0414 |
| DOI: | 10.1093/alcalc/agm037 |
| Popis: | The purpose of this study was to investigate the role of K + channels in duodenal dismotility induced by ethanol in vitro. The amplitude of spontaneous contractions was reduced by ethanol in longitudinal and circular muscle, while frequency did not change. Charybdotoxin antagonized ethanol-induced inhibition of the amplitude of spontaneous contractions. Ethanol decreased ACh-induced contractions and this effect was cancelled out by charybdotoxin. Ca 2+ -activated K + channels may be involved in duodenal dismotility induced by ethanol. |
| Databáze: | OpenAIRE |
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